|
Pronunciation |
|
(am
SIN oh
nide) |
|
|
U.S. Brand
Names |
|
Cyclocort®
Topical |
|
|
Generic
Available |
|
No |
|
|
Pharmacological Index |
|
Corticosteroid, Topical |
|
|
Use |
|
Relief of the inflammatory and pruritic manifestations of
corticosteroid-responsive dermatoses (high potency
corticosteroid) |
|
|
Pregnancy Risk
Factor |
|
C |
|
|
Contraindications |
|
Hypersensitivity to amcinonide or any component; use on the face, groin, or
axilla |
|
|
Warnings/Precautions |
|
Adverse systemic effects may occur when used on large areas of the body,
denuded areas, for prolonged periods of time, with an occlusive dressing, and/or
in infants or small children; occlusive dressings should not be used in presence
of infection or weeping lesions |
|
|
Adverse
Reactions |
|
1% to 10%:
Dermatologic: Itching, maceration of skin, skin atrophy, erythema, dryness,
papular rashes
Local: Burning, irritation
<1%: Hypertrichosis, acneiform eruptions, hypopigmentation, perioral
dermatitis, striae, miliaria |
|
|
Overdosage/Toxicology |
|
Symptoms of overdose include cushingoid appearance (systemic), muscle
weakness (systemic), osteoporosis (systemic) all with long-term use only. When
consumed in excessive quantities for prolonged periods, systemic hypercorticism
and adrenal suppression may occur; in those cases, discontinuation and
withdrawal of the corticosteroid should be done
judiciously. |
|
|
Drug
Interactions |
|
No data reported |
|
|
Mechanism of
Action |
|
Stimulates the synthesis of enzymes needed to decrease inflammation, suppress
mitotic activity, and cause vasoconstriction |
|
|
Pharmacodynamics/Kinetics |
|
Absorption: Adequate through intact skin; increases with skin inflammation or
occlusion
Metabolism: In the liver
Elimination: By the kidney and in bile |
|
|
Usual Dosage |
|
Adults: Topical: Apply in a thin film 2-3 times/day. Therapy should be
discontinued when control is achieved; if no improvement is seen, reassessment
of diagnosis may be necessary. |
|
|
Mental Health: Effects
on Mental Status |
|
None reported |
|
|
Mental Health:
Effects on Psychiatric
Treatment |
|
None reported |
|
|
Dental Health: Local
Anesthetic/Vasoconstrictor
Precautions |
|
No information available to require special precautions |
|
|
Dental Health:
Effects on Dental Treatment |
|
No effects or complications reported |
|
|
Patient
Information |
|
Before applying, gently wash area to reduce risk of infection; apply a thin
film to cleansed area and rub in gently and thoroughly until medication
vanishes; avoid exposure to sunlight, severe sunburn may
occur |
|
|
Nursing
Implications |
|
Assess for worsening of rash or fever |
|
|
Dosage Forms |
|
Cream: 0.1% (15 g, 30 g, 60 g)
Lotion: 0.1% (20 mL, 60 mL)
Ointment, topical: 0.1% (15 g, 30 g, 60 g)
|
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