Yes

Blood Product Derivative; Plasma Volume Expander, Colloid

Plasma volume expansion and maintenance of cardiac output in the treatment of certain types of shock or impending shock; may be useful for burn patients, ARDS, and cardiopulmonary bypass; other uses considered by some investigators (but not proven) are retroperitoneal surgery, peritonitis, and ascites; unless the condition responsible for hypoproteinemia can be corrected, albumin can provide only symptomatic relief or supportive treatment; nutritional supplementation is not an appropriate indication for albumin

C

Patients with severe anemia or cardiac failure, known hypersensitivity to albumin; avoid 25% concentration in preterm infants due to risk of idiopathic ventricular hypertrophy

Use with caution in patients with hepatic or renal failure because of added protein load; rapid infusion of albumin solutions may cause vascular overload. All patients should be observed for signs of hypervolemia such as pulmonary edema. Use with caution in those patients for whom sodium restriction is necessary. Rapid infusion may cause hypotension.

1% to 10%:

Central nervous system: Fever, chills

Dermatologic: Rash

Gastrointestinal: Nausea, vomiting

Respiratory: Pulmonary edema

Symptoms of overdose include hypervolemia, congestive heart failure, pulmonary edema

Do not use solution if it is turbid or contains a deposit; use within 4 hours after opening vial

Provides increase in intravascular oncotic pressure and causes mobilization of fluids from interstitial into intravascular space

I.V.:

25% should be used in patients in whom fluid and sodium intake must be minimized

Dose depends on condition of patient:

Children:

Emergency initial dose: 25 g

Nonemergencies: 25% to 50% of the adult dose

Adults: Usual dose: 25 g; no more than 250 g should be administered within 48 hours

Hypoproteinemia: 0.5-1 g/kg/dose; repeat every 1-2 days as calculated to replace ongoing losses

Hypovolemia: 0.5-1 g/kg/dose; repeat as needed; maximum dose: 6 g/kg/day

alkaline phosphatase (S)

None reported

None reported

Pregnancy precautions: Inform prescriber if you are pregnant.

Albumin administration must be completed within 4 hours after entering container, provided that administration is begun within 4 hours of entering the container; use 5 micron filter or larger, do not administer through 0.22 micron filter

Parenteral: I.V. after initial volume replacement:

5%: Do not exceed 2-4 mL/minute

25%: Do not exceed 1 mL/minute

Observe for signs of hypervolemia, pulmonary edema, and cardiac failure

Injection, as human: 5% [50 mg/mL] (50 mL, 250 mL, 500 mL, 1000 mL); 25% [250 mg/mL] (10 mL, 20 mL, 50 mL, 100 mL)