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St. John's Wort | ||
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| Pronunciation |
 (a
DEF o
veer) |
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| U.S. Brand Names |
| Preveon™ |
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| Generic Available |
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No |
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| Pharmacological Index |
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Antiretroviral Agent, Reverse Transcriptase Inhibitor (Nucleoside) |
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| Use |
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Investigational (8/1/98); treatment of HIV infections in combination with at least two other antiretroviral agents; also has some activity against hepatitis B virus and herpes viruses |
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| Pregnancy Risk Factor |
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Not available |
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| Adverse Reactions |
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Endocrine & metabolic: Elevation of transaminases, hot flashes Gastrointestinal: GI symptoms Genitourinary: Urethritis Hematologic: Elevation of hemoglobin |
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| Mechanism of Action |
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Acyclic nucleotide reverse transcriptase inhibitor which interferes with HIV viral RNA dependent DNA polymerase resulting in inhibition of viral replication |
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| Pharmacodynamics/Kinetics |
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Serum half-life: 1.6 hours; 16-18 hours intracellularly |
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| Usual Dosage |
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Oral: Hepatitis B: 125 mg once daily |
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| Dental Health: Local Anesthetic/Vasoconstrictor Precautions |
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No information available to require special precautions |
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| Dental Health: Effects on Dental Treatment |
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No effects or complications reported |
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| Patient Information |
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This is not a cure for AIDS or AIDS complex, nor will it reduce the risk of transmission to others. Long-term effects are not known. You may need frequent blood tests to adjust dosage for maximum therapeutic effect. Take as directed, for full course of therapy; do not discontinue (even if feeling better). You may experience hot flashes (cool environment or cool clothes may help); nausea or vomiting (small, frequent meals, chewing gum, or sucking on lozenges may help); difficulty breathing; or rash. Inform prescriber if you are or intend to be pregnant. Do not breast-feed. |
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