No

Acne Products

Treatment of acne vulgaris

C

Clinical effects on the fetus: No teratogenic effects were seen in rats at oral doses of adapalene 0.15-5 mg/kg/day

Breast feeding/lactation: There are no adequate and well controlled studies in pregnant women; it is not known whether adapalene is excreted in breast milk

Hypersensitivity to adapalene or any of the components in the vehicle gel

Use with caution in patients with eczema; avoid excessive exposure to sunlight and sunlamps; avoid contact with abraded skin, mucous membranes, eyes, mouth, angles of the nose

>10%: Dermatologic: Erythema, scaling, dryness, pruritus, burning, pruritus or burning immediately after application

less than or equal to 1%: Skin irritation, stinging sunburn, acne flares; dermatitis, contact dermatitis, eyelid edema, conjunctivitis, skin discoloration, eczema, rash

Toxic signs of an overdose commonly respond to drug discontinuation, and generally return to normal spontaneously within a few days to weeks

When confronted with signs of increased intracranial pressure, treatment with mannitol (0.25 g/kg I.V. up to 1 g/kg/dose repeated every 5 minutes as needed), dexamethasone (1.5 mg/kg I.V. load followed with 0.375 mg/kg every 6 hours for 5 days), and/or hyperventilation should be employed

Retinoid-like compound which is a modulator of cellular differentiation, keratinization and inflammatory processes, all of which represent important features in the pathology of acne vulgaris

Absorption: Topical: Minimum absorption occurs

Elimination: In bile

Children >12 years and Adults: Topical: Apply once daily at bedtime; therapeutic results should be noticed after 8-12 weeks of treatment

No information available to require special precautions

No effects or complications reported

For external use only. Apply with gloves in thin film at night to thoroughly clean/dry skin; avoid area around eyes or mouth. Do not apply occlusive dressing. Results make take 8-12 weeks to appear. You may experience transient burning or stinging immediately after applying. Report worsening of condition or skin redness, dryness, peeling, or burning that persists between applications. Pregnancy/breast-feeding precautions: Inform prescriber if you are or intend to be pregnant. Consult prescriber if breast-feeding.

Observe for signs of hypersensitivity, blistering, excessive dryness; do not apply to mucous membranes

Cream, topical (Differin®): 0.1%

Gel, topical (alcohol free): 0.1% (15 g, 45 g)