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Pronunciation |
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(a
SEE tik AS
id) |
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U.S. Brand
Names |
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Aci-jel® Vaginal; VoSol®
Otic |
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Generic
Available |
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Yes |
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Synonyms |
|
Ethanoic Acid |
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|
Pharmacological Index |
|
Otic Agent, Anti-infective; Topical Skin Product |
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|
Use |
|
Irrigation of the bladder; treatment of superficial bacterial infections of
the external auditory canal and vagina |
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Pregnancy Risk
Factor |
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C |
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Contraindications |
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During transurethral procedures; hypersensitivity to drug or
components |
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Warnings/Precautions |
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Not for internal intake or I.V. infusion; topical use or irrigation use only;
use of irrigation in patients with mucosal lesions of urinary bladder may cause
irritation; systemic acidosis may result from absorption |
|
|
Adverse
Reactions |
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<1%: Systemic acidosis, urologic pain, hematuria |
|
|
Usual Dosage |
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Irrigation (note dosage of an irrigating solution depends on the capacity or
surface area of the structure being irrigated):
For continuous irrigation of the urinary bladder with 0.25% acetic acid
irrigation, the rate of administration will approximate the rate of urine flow;
usually 500-1500 mL/24 hours
For periodic irrigation of an indwelling urinary catheter to maintain
patency, about 50 mL of 0.25% acetic acid irrigation is required
Otic: Insert saturated wick; keep moist 24 hours; remove wick and instill 5
drops 3-4 times/day
Vaginal: One applicatorful every morning and evening |
|
|
Administration |
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Not for internal intake or I.V. infusion; topical use or irrigation use
only |
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Nursing
Implications |
|
For continuous or intermittent irrigation of the urinary bladder, urine pH
should be checked at least 4 times/day and the irrigation rate adjusted to
maintain a pH of 4.5-5 |
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Dosage Forms |
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Jelly vaginal: 0.921% with oxyquinolone sulfate 0.025%, ricinoleic acid 0.7%,
and glycerin 5% (85 g)
Solution:
Irrigation: 0.25% (1000 mL)
Otic: Acetic acid 2% in propylene glycol (15 mL, 30 mL, 60 mL)
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References |
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Kawamata M, Fujita S, and Mayumi T,
"Acetic Acid Intoxication by Rectal Administration," J Toxicol Clin
Toxicol, 1994, 32(3):333-6.
Penner GE, "Acid Ingestion: Toxicology and Treatment," Ann Emerg Med,
1980, 9(7):374-9. |
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