Yes

Analgesic, Miscellaneous

Relief of mild to moderate pain; sinus headache

See individual agents

Oral: Adults: Take 2 caplets or 5 mL of liquid at bedtime or as directed by physician; do not exceed recommended dosage; not for use in children <12 years of age

Drowsiness is common

Concurrent use with CNS depressant may result in additive CNS depression. MAOI may cause additive anticholinergic effects.

No information available to require special precautions

1% to 10% of patients may experience dry mouth

Caplet:

Excedrin® P.M.: Acetaminophen 500 mg and diphenhydramine citrate 30 mg

Midol® PM: Acetaminophen 500 mg and diphenhydramine 25 mg

Liquid (wild berry flavor) (Excedrin® P.M.): Acetaminophen 1000 mg and diphenhydramine hydrochloride 50 mg per 30 mL (180 mL)

Barker JD Jr, de Carle DJ, and Anuras S, "Chronic Excessive Acetaminophen Use in Liver Damage," Ann Intern Med, 1977, 87(3):299-301.

Dionne RA, Campbell RA, Cooper SA, et al, "Suppression of Postoperative Pain by Preoperative Administration of Ibuprofen in Comparison to Placebo, Acetaminophen, and Acetaminophen Plus Codeine," J Clin Pharmacol, 1983, 23(1):37-43.

Licht H, Seeff LB, and Zimmerman HJ, "Apparent Potentiation of Acetaminophen Hepatotoxicity by Alcohol," Ann Intern Med, 1980, 92(4):511.