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| Pronunciation |
 (a
seet a MIN oh fen, eye soe me THEP
teen, & dye KLOR al FEN a zone) |
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| U.S. Brand Names |
| Isocom®; Isopap®; Midchlor®; Midrin®; Migratine® |
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| Generic Available |
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Yes |
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| Pharmacological Index |
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Analgesic, Miscellaneous |
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| Use |
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Relief of migraine and tension headache |
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| Pregnancy Risk Factor |
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B |
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| Contraindications |
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Glaucoma; severe renal disease; hypertension; organic heart disease; hepatic disease; MAO inhibitor therapy |
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| Adverse Reactions |
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Central nervous system: Transient dizziness Dermatological: Rash |
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| Usual Dosage |
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Adults: Oral: 2 capsules at first sign of headache, followed by 1 capsule every 60 minutes until relieved, up to 5 capsules in a 12-hour period |
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| Mental Health: Effects on Mental Status |
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May cause drowsiness or dizziness |
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| Mental Health: Effects on Psychiatric Treatment |
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Contraindicated with MAOI |
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| Dental Health: Local Anesthetic/Vasoconstrictor Precautions |
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No information available to require special precautions |
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| Dental Health: Effects on Dental Treatment |
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No effects or complications reported |
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| Dosage Forms |
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Capsule: Acetaminophen 325 mg, isometheptene mucate 65 mg, dichloralphenazone 100 mg |
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| References |
|
Barker JD Jr, de Carle DJ, and Anuras S, "Chronic Excessive Acetaminophen Use in Liver Damage," Ann Intern Med, 1977, 87(3):299-301. Dionne RA, Campbell RA, Cooper SA, et al, "Suppression of Postoperative Pain by Preoperative Administration of Ibuprofen in Comparison to Placebo, Acetaminophen, and Acetaminophen Plus Codeine," J Clin Pharmacol, 1983, 23(1):37-43. Licht H, Seeff LB, and Zimmerman HJ, "Apparent Potentiation of Acetaminophen Hepatotoxicity by Alcohol," Ann Intern Med, 1980, 92(4):511. |
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