Acetaminophen, Dextromethorphan, and Pseudoephedrine

Interactions with herbs

Milk Thistle

Interactions with supplements

S-Adenosylmethionine (SAMe)

Vitamin C (Ascorbic Acid)

Look Up > Drugs > Acetaminophen, Dextromethorphan, and Pseudoephedrine

Acetaminophen, Dextromethorphan, and Pseudoephedrine

	Pronunciation
	U.S. Brand Names
	Generic Available
	Synonyms
	Pharmacological Index
	Use
	Warnings/Precautions

	Adverse Reactions
	Usual Dosage
	Mental Health: Effects on Mental Status
	Mental Health: Effects on Psychiatric Treatment
	Dental Health: Local Anesthetic/Vasoconstrictor Precautions
	Dental Health: Effects on Dental Treatment
	Dosage Forms

Pronunciation

(a seet a MIN oh fen, deks troe meth OR fan, & soo doe e FED rin)

U.S. Brand Names

Alka-Seltzer® Plus Flu & Body Aches Non-Drowsy Liqui-Gels®[OTC]; Comtrex® Maximum Strength Non-Drowsy [OTC]; Sudafed® Severe Cold [OTC]; Theraflu® Non-Drowsy Formula Maximum Strength [OTC]; Tylenol® Cold No Drowsiness [OTC]; Tylenol® Flu Maximum Strength [OTC]

Generic Available

Yes

Synonyms

Dextromethorphan, Acetaminophen, and Pseudoephedrine; Pseudoephedrine, Acetaminophen, and Dextromethorphan; Pseudoephedrine, Dextromethorphan, and Acetaminophen

Pharmacological Index

Antihistamine; Antitussive

Use

Treatment of mild to moderate pain and fever; symptomatic relief of cough and congestion

Warnings/Precautions

Research on chicken embryos exposed to concentrations of dextromethorphan relative to those typically taken by humans has shown to cause birth defects and fetal death; more study is needed, but it is suggested that pregnant women should be advised not to use dextromethorphan-containing medications

Adverse Reactions

See individual agents

Usual Dosage

Adults: Oral: 2 tablets every 6 hours

Mental Health: Effects on Mental Status

Sedation with dextromethorphan tends to be countered by the excitability associated with pseudoephedrine; one effect may predominate in any particular patient

Mental Health: Effects on Psychiatric Treatment

Increased toxicity and hypertensive crisis may be seen with concurrent use of MAOIs and CNS depressants, effects of CNS depressants may be lessened

Dental Health: Local Anesthetic/Vasoconstrictor Precautions

No information available to require special precautions

Dental Health: Effects on Dental Treatment

No effects or complications reported

Dosage Forms

Tablet:

Tylenol® Cold No Drowsiness: Acetaminophen 325 mg, dextromethorphan hydrobromide 15 mg, and pseudoephedrine hydrochloride 30 mg

Comtrex® Maximum Strength Non-Drowsy; Sudafed® Severe Cold; Theraflu® Non-Drowsy Formula Maximum Strength; Tylenol® Flu Maximum Strength: Acetaminophen 500 mg, dextromethorphan hydrobromide 15 mg, and pseudoephedrine hydrochloride 30 mg