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Pronunciation |
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(a
seet a MIN oh fen, klor fen IR a
meen, & soo doe e FED rin) |
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U.S. Brand
Names |
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Alka-Seltzer® Plus Cold
Liqui-Gels®[OTC]; Aspirin-Free Bayer®
Select® Allergy Sinus Caplets [OTC]; Co-Hist®[OTC];
Sinutab® Tablets
[OTC] |
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Generic
Available |
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Yes |
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Pharmacological Index |
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Analgesic, Miscellaneous; Antihistamine |
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|
Use |
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Temporary relief of sinus symptoms |
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Pregnancy Risk
Factor |
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B |
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Adverse
Reactions |
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See individual agents |
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Usual Dosage |
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Adults: Oral: 2 tablets every 6 hours |
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Mental Health: Effects
on Mental Status |
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Sedation with chlorpheniramine is countered by the excitability associated
with pseudoephedrine; one effect may predominate in any particular
patient |
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Mental Health:
Effects on Psychiatric
Treatment |
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Usually none; sedative effect of chlorpheniramine may be potentiated by other
CNS depressants and MAOIs |
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Dental Health: Local
Anesthetic/Vasoconstrictor
Precautions |
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Use with caution since pseudoephedrine is a sympathomimetic amine which could
interact with epinephrine to cause a pressor response |
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Dental Health:
Effects on Dental Treatment |
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Chlorpheniramine: Prolonged use will cause significant xerostomia
Pseudoephedrine: Up to 10% of patients could experience tachycardia,
palpitations, and dry mouth; use vasoconstrictor with caution
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Dosage Forms |
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Caplet: Acetaminophen 500 mg, chlorpheniramine maleate 2 mg, and
pseudoephedrine hydrochloride 30 mg
Capsule: Acetaminophen 250 mg, chlorpheniramine maleate 2 mg, and
pseudoephedrine hydrochloride 30 mg
Tablet: Acetaminophen 325 mg, chlorpheniramine maleate 2 mg, and
pseudoephedrine hydrochloride 30 mg |
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References |
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Barker JD Jr, de Carle DJ, and Anuras S,
"Chronic Excessive Acetaminophen Use in Liver Damage," Ann Intern Med,
1977, 87(3):299-301.
Dionne RA, Campbell RA, Cooper SA, et al,
"Suppression of Postoperative Pain by Preoperative Administration of Ibuprofen in Comparison to Placebo, Acetaminophen, and Acetaminophen Plus Codeine,"
J Clin Pharmacol, 1983, 23(1):37-43.
Licht H, Seeff LB, and Zimmerman HJ,
"Apparent Potentiation of Acetaminophen Hepatotoxicity by Alcohol," Ann
Intern Med, 1980, 92(4):511. |
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