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Look Up > Drugs > Acetaminophen, Aspirin, and Caffeine
Acetaminophen, Aspirin, and Caffeine
Pronunciation
U.S. Brand Names
Generic Available
Pharmacological Index
Use
Pregnancy Risk Factor
Adverse Reactions
Usual Dosage
Mental Health: Effects on Mental Status
Mental Health: Effects on Psychiatric Treatment
Dental Health: Local Anesthetic/Vasoconstrictor Precautions
Dental Health: Effects on Dental Treatment
Dosage Forms
References

Pronunciation
(a seet a MIN oh fen, AS pir in, & KAF een)

U.S. Brand Names
Excedrin®, Extra Strength [OTC]; Gelpirin®[OTC]; Goody's® Headache Powders

Generic Available

Yes


Pharmacological Index

Analgesic, Miscellaneous


Use

Relief of mild to moderate pain


Pregnancy Risk Factor

D


Adverse Reactions

See individual agents


Usual Dosage

Adults: Oral: 1-2 tablets every 2-6 hours as needed for pain


Mental Health: Effects on Mental Status

May cause anxiety, insomnia, and excitability


Mental Health: Effects on Psychiatric Treatment

Effects of CNS depressants may be lessened by caffeine component


Dental Health: Local Anesthetic/Vasoconstrictor Precautions

No information available to require special precautions


Dental Health: Effects on Dental Treatment

No effects or complications reported


Dosage Forms

Geltab: Acetaminophen 250 mg, aspirin 250 mg, and caffeine 65 mg

Powder: Acetaminophen 250 mg, aspirin 520 mg, and caffeine 32.5 mg per dose

Tablet: Acetaminophen 125 mg, aspirin 240 mg, and caffeine 32 mg; acetaminophen 250 mg, aspirin 250 mg, and caffeine 65 mg


References

Barker JD Jr, de Carle DJ, and Anuras S, "Chronic Excessive Acetaminophen Use in Liver Damage," Ann Intern Med, 1977, 87(3):299-301.

Desjardins PJ, Cooper SA, Gallegos TL, et al, "The Relative Analgesic Efficacy of Propiram Fumarate, Codeine Aspirin, and Placebo in Post-Impaction Dental Pain," J Clin Pharmacol, 1984, 24(1):35-42.

Dionne RA, Campbell RA, Cooper SA, et al, "Suppression of Postoperative Pain by Preoperative Administration of Ibuprofen in Comparison to Placebo, Acetaminophen, and Acetaminophen Plus Codeine," J Clin Pharmacol, 1983, 23(1):37-43.

Forbes JA, Butterworth GA, Burchfield WH, et al, "Evaluation of Ketorolac, Aspirin, and an Acetaminophen-Codeine Combination in Postoperative Oral Surgery Pain," Pharmacotherapy, 1990, 10(6 Pt 2):77S-93S.

Forbes JA, Keller CK, Smith JW, et al, "Analgesic Effect of Naproxen Sodium, Codeine, a Naproxen-Codeine Combination and Aspirin on the Postoperative Pain of Oral Surgery," Pharmacotherapy, 1986, 6(5):211-8.

Licht H, Seeff LB, and Zimmerman HJ, "Apparent Potentiation of Acetaminophen Hepatotoxicity by Alcohol," Ann Intern Med, 1980, 92(4):511.


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