Azelastine nasal spray is indicated for the local treatment of the symptoms of seasonal allergic rhinitis and perennial allergic rhinitis, such as rhinorrhea, sneezing and nasal pruritis in adults and children 5 years of age and older.
In some countries, it is also indicated for the treatment of vasomotor rhinitis in adults and children ≥ 12 years old.
Azelastine eyes drops are indicated for the local treatment of seasonal and perennial allergic conjunctivitis.
Azelastine is a potent, second-generation, selective, histamine antagonist (histamine-H1-receptor antagonist) manufactured by MedaPharma.
According to the Allergic Rhinitis and its Impact on Asthma (ARIA) treatment guidelines, intranasal anti-histamines are recommended for the first line therapy of mild intermittent, moderate/severe intermittent and mild persistent rhinitis (new classification system for rhinitis).
Azelastine has been formulated both as a nasal spray (0.1% and 0.15% solutions) and as eye drops (0.05% solution).
: side effects.
bitter taste , tiredness
weight increase , muscle pain
nasal burning
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Azelastine is safe and well-tolerated in both adults and children (≥12 years) with allergic rhinitis.[31][32] Bitter taste, headache, nasal burning and somnolence are the most frequently reported adverse events.