Ranitidine HCL

dr.joandr.joan عضو ماسي
تم تعديل 2009/08/25 في أدوية الطوارئ Emergency drugs
Trade names: Zantac , Randine
Class: ulcer healing drug "H2-receptor antagonists "
Pregnancy: (Category B)
It competitively inhibits gastric acid secretion by blocking the effect of
histamine on histamine H2-receptors.
Short-term (up to 8 wks) & maintenance treatment of duodenal ulcer &
treatment of benign gastric ulcer .
Management of hypersecretion of gastric acid .
Reflux esophagitis.
by mouth, 150 mg twice daily or 300 mg at night
Prophylaxis of NSAID-induced duodenal ulcer, 150 mg twice daily
Reflux oesophagitis, 150 mg twice daily or 300 mg at night for up to 8 weeks, By intramuscular injection, 50 mg every 6–8 hours
By slow intravenous injection, 50 mg diluted to 20 mL and given over at least 2 minutes; may be repeated every 6–8 hours
Prophylaxis of stress ulceration, initial slow intravenous injection of 50 mg then continuous infusion, 125–250 micrograms/kg per hour
Liver cirrhosis, impaired renal & hepatic function .
Side effects:
Constipation , nausea , vomiting, diarrhea, headache
Dizziness , malaise , vertigo , bradycardia or tachycardia
Pancytopnea , rashes, bronchospasm , alopecia.
Nursing considerations:
  • Dilute for I.V. use ( 50 mg in 20 ml of 0.9% Nacl) .
  • Note any evidence of renal or liver disease.
  • Obtain baseline liver & kidney function.
  • Note for signs of infection .
Adequate hydration for problem of diarrhea