Class: Antiarrhythmic " class І "
Trade names: Apo-Quinidine; Biquin Durules; Cardioquin; Novoquinidin; Quin-Release; Quinaglute Dura-tabs; Quinate; Quinidex Extentabs.
: (Category C)
v Quinidine works by decreasing the sensitivity of heart muscle cells to electrical impulses, therefore slowing the electrical conduction in the heart muscle.
v Quinidine is used to treat two forms of arrhythmia - ventricular and supraventricular arrhythmias.
Irregular heart beats (arrhythmias)
Use with caution in
Allergic reaction to one of the active ingredients
by mouth, quinidine sulphate 200–400 mg 3–4 times daily
- Defect of the heart's electrical message pathways resulting in decreased function of the heart (heart block)
- This medicine should not be used if you are allergic to one or any of its ingredients.
- Certain medicines should not be used during pregnancy or breastfeeding.
Inability of the heart to pump blood efficiently (heart failure)
Disturbances of the gut such as diarrhea, constipation, nausea, vomiting or abdominal pain
Irregular heart beat (ventricular arrhythmias)
Decreased electrical impulses within the heart (myocardial depression)
A test dose of a single tablet of quinidine sulfate (200 mg) by mouth should be given initially in order to ascertain any possible hypersensitivity to quinidine. Hypersensitivity to quinidine, although rare, should be constantly considered, especially during the first week of therapy.
Continuous ECG monitoring is recommended in all cases in which quinidine is used in large doses.
Gastrointestinal symptoms such as nausea, vomiting, diarrhea and colic may be minimized by giving the drug with food.