Class: Antidiarrheals, hormones
Trade names: Sandostatin
Suppresses secretion of serotonin and gastroenterohepatic peptides
Increases absorption of fluid and electrolytes from the GI tract and increases transit time
Decreases levels of serotonin metabolites
Also suppresses growth hormone, insulin, and glucagon.
prophylaxis following pancreatic trauma or surgery subcutaneous every 8 hours, 100 mic/kg
In esophageal varices 50-100 mic IV injection then infusion of 25 – 50 mic/hour for 2-3 days
Gallbladder disease (increased risk of stone formation)
Renal impairment (dosage reduction may be necessary)
Hyperglycemia or hypoglycemia (changes in blood sugar may occur)
Fat malabsorption (may be aggravated)
Pregnancy or lactation (safety not established).
§ CNS: dizziness, drowsiness, fatigue, headache, weakness.
§ EENT: visual disturbances.
§ CV: edema, orthostatic hypotension, palpitations.
§ GI: abdominal pain, cholelithiasis, diarrhea, fat malabsorption, nausea, vomiting.
§ Derm: flushing.
§ Endo: hyperglycemia, hypoglycemia.
§ Local: injection site pain.
§ Sandostatin ampoules and multi-dose vials should be stored at refrigerated temperatures 2-8°C (36-46°F) and protected from light.
§ Because the drug may result in hypoglycemia or hyperglycemia monitor blood glucose level for the pt.
§ Cardiac conduction abnormalities have also occurred during treatment with Sandostatin so the nurse should monitor the pt's vital signs , ECG…etc.