Class: Proton Pump Inhibitors " Ulcer-healing drugs
Trade names: Prilosec
Pregnancy: (Category C)
Management of GERD
Management of duodenal ulcers (with or without anti-infective for H. pylori)
Treatment of pathologic hypersecretory conditions, including Zollinger-Ellison syndrome.
by mouth, prophylaxis against stress ulcer 20 mg/12 hours,
NSAID-associated duodenal or gastric ulcer and gastroduodenal erosions, 20 mg once daily for 4 weeks, followed by a further 4 weeks if not fully healed; prophylaxis in patients with a history of NSAID-associated duodenal or gastric ulcers, gastroduodenal lesions, or dyspeptic symptoms who require continued NSAID treatment, 20 mg once daily
Gastric acid reduction during general anaesthesia (prophylaxis of acid aspiration), 40 mg on the preceding evening then 40 mg 2–6 hours before surgery
CHILD over 2 years, severe ulcerating reflux oesophagitis, 0.7–1.4 mg/kg daily for 4–12 weeks; max. 40 mg daily (to be initiated by hospital paediatrician)
Liver disease (dosage reduction may be necessary)
Pregnancy, lactation, or children (safety not established).
CNS: dizziness, drowsiness, fatigue, headache, weakness.
CV: chest pain.
GI: abdominal pain, acid regurgitation, constipation, diarrhea, flatulence, nausea, vomiting.
Derm: itching, rash.
Misc: allergic reactions.
Nurse should instruct the pt to take each dose of Prilosec with a full glass (8 ounces) of water.
Prilosec is usually taken before eating.