dr.joandr.joan عضو ماسي
تم تعديل 2009/07/07 في أدوية الطوارئ Emergency drugs
Omeprazole :
Trade names: Prilosec
Class: Proton Pump Inhibitors " Ulcer-healing drugs
Pregnancy: (Category C)
  • Binds to an enzyme on gastric parietal cells in the presence of acidic gastric pH, preventing the final transport of hydrogen ions into the gastric lumen.
  • Therapeutic Effects:
    • Diminished accumulation of acid in the gastric lumen with lessened gastroesophageal reflux
    • Healing of duodenal ulcers.
  • Management of GERD
  • Management of duodenal ulcers (with or without anti-infective for H. pylori)
  • Treatment of pathologic hypersecretory conditions, including Zollinger-Ellison syndrome.
by mouth, prophylaxis against stress ulcer 20 mg/12 hours,
NSAID-associated duodenal or gastric ulcer and gastroduodenal erosions, 20 mg once daily for 4 weeks, followed by a further 4 weeks if not fully healed; prophylaxis in patients with a history of NSAID-associated duodenal or gastric ulcers, gastroduodenal lesions, or dyspeptic symptoms who require continued NSAID treatment, 20 mg once daily
Gastric acid reduction during general anaesthesia (prophylaxis of acid aspiration), 40 mg on the preceding evening then 40 mg 2–6 hours before surgery
CHILD over 2 years, severe ulcerating reflux oesophagitis, 0.7–1.4 mg/kg daily for 4–12 weeks; max. 40 mg daily (to be initiated by hospital paediatrician)
  • Hypersensitivity.
Use Cautiously in:
  • Liver disease (dosage reduction may be necessary)
  • Pregnancy, lactation, or children (safety not established).
Side effects:
CNS: dizziness, drowsiness, fatigue, headache, weakness.
CV: chest pain.
GI: abdominal pain, acid regurgitation, constipation, diarrhea, flatulence, nausea, vomiting.
Derm: itching, rash.
Misc: allergic reactions.
Nursing considerations:
Nurse should instruct the pt to take each dose of Prilosec with a full glass (8 ounces) of water.
Prilosec is usually taken before eating.