Class: Vasoconstrictor sympathomimetics
Trade names: Norepinephrine
Pregnancy: (Category C)
Noradrenalin (Norepinephrine) tartrate is a substance released naturally by the nerve cells. It produces wide ranging effects on many areas of the body and is often referred to as a 'fight or flight' chemical, as it is responsible for the body's reaction to stressful situations.
A severe form of angina pectoris, not caused by exertion (Prinzmetal's angina)
Abnormally high amount of carbon dioxide in the blood (hypercabnia)
Blood clot in one of the blood vessels in the extremities (peripheral vascular thrombosis)
Blood clot in the artery which supplies blood to the heart (coronary thrombosis)
Blood clot in the artery which supplies blood to the intestines (mesenteric thrombosis)
Low blood pressure following a heart attack
Low levels of oxygen in the tissues (hypoxia)
Acute hypotension, by intravenous infusion, via central venous catheter, of a solution containing noradrenaline acid tartrate 80 micrograms/mL (equivalent to noradrenaline base 40 micrograms/mL) at an initial rate of 0.16–0.33 mL/minute, adjusted according to response
Slow heart rate (bradycardia)
High blood pressure (hypertension)
Inadequate blood flow leading to low levels of oxygen in the tissues of the extremities (peripheral ischemia), which may lead to gangrene
The infusion must be changed every 24 hours ·
Monitor urine output hourly and check distal pulses ·
Monitor serum glucose.
Give via volumetric pump to regulate flow.
During infusion monitor ECG,BP, CO, CVP, PAWP, HR, urine output, color and temperature of extremities initially every 2 minutes.
Check infusion site frequently for signs of extravasation If occurs stop infusion immediately, infiltrate the area with 5 - 10 mg Phentolamine(alpha blocker) diluted in 10 - 15 ml 0.9 % normal saline subcutaneously and liberally