Trade names: Pramin
It is dopamine receptor antagonist acts both centrally & peripherally,
gastric emptying & intestinal transit
centrally due to the effect in the CTZ ( inhibition) , Peripherally it
stimulate the motility of the upper GIT without affecting gastric &
biliary or pancreatic secretions. It relaxes the pyloric sphincter &
increases the peristalsis of the duodenum resulting in accelerated
- Digestive disorders leading to relief GIT pain , Dyspepsia & regurgitation in peptic ulcer, reflux esophagitis & postanasthetic vomiting.
- Nausea & vomiting as in chemotherapy.
- Facilitate diagnostic procedure e.g. barium meal.
by mouth, or by intramuscular injection or by intravenous injection over 1–2 minutes, 10 mg (5 mg in young adults 15–19 years under 60 kg) 3 times daily; CHILD up to 1 year (up to 10 kg) 1 mg twice daily, 1–3 years (10–14 kg) 1 mg 2–3 times daily, 3–5 years (15–19 kg) 2 mg 2–3 times daily, 5–9 years (20–29 kg) 2 mg 3 times daily, 9–14 years (30 kg and over) 5 mg 3 times daily
Note. Daily dose of metoclopramide should not normally exceed 500 micrograms/kg, particularly for children and young adults.
ü Seizure (epilepsy) ,
ü Pheochromocytoma , &
ü Intestinal obstruction.
ü GI disturbances,
ü transient hypertension,
ü supraventricular tachycardia,
ü dizziness &
ü extrapyramidal effect “convulsion”.
§ Don’t give pramin to patients with epilepsy, pheochromocytomes or patients with intestinal obstruction.
§ Administer oral medication 30 minutes before meal & at bed time .
§ Administer I.V. injection slowly over 1-2 minutes.
§ Be aware of the extrapyramidal symptoms specially in children