Glibenclamide ' Daonil '

dr.joandr.joan عضو ماسي
تم تعديل 2009/06/28 في أدوية الطوارئ Emergency drugs
Glibenclamide ' Daonil ' :
Trade name: daonil.
Pregnancy: (Category C)

Class: First generation sulfonylurea.
Indication:
Non- insulin dependent diabetes mellitus (NIDDM) (type II).
· Patients should be subjected to a 7 day therapeutic trial.
· Decrease in blood sugar, decrease in glucosuria & disappearance of Polyuria, polydipsia, & polyphagia indicate that patient can be managed on oral antidiabetic agents.
Contraindications:
§ Type I of D.M.
§ Renal & liver disease.
§ Diabetes complicated by recurrent episodes of ketoacidosis.
Dose:
Initially ½ -1 tablet (5mg) daily, increased by 2.5 – 5 mg weekly to achieve the desired response. max. 15 mg daily.
Side effects:
§ Hypoglycemia (most common).
§ Nausea, heartburn, diarrhea
§ Headache, dizziness, general weakness.
§ Pancytopnea.
§ Chronic use increases risk of cardiovascular mortality.
§ Cholestatic jaundice (rare).
Nursing considerations:
§ Drugs may be taken with food to minimize GI upset.
§ Stop the medication if signs of side-effects or ketoacidosis appear
§ Explain the importance of carrying candy or sugar at all times to counteract hypoglycemia should it occur.
§ Provide the client & family with a printed chart explaining symptoms of hypoglycemia, hyperglycemia & instructions concerning what to do for each.
§ Explain the importance of exercise & adhering to the prescribed diet.