Ceftriaxone

dr.joan

5. Ceftriaxone:
Trade name: Rocephin
Class: Antibiotic "cephalosporines" third-generation
Pregnancy: (Category

Action: Bind to bacterial cell wall membrane, causing cell death.
Uses:

• Pneumonia, UTI, infections of skin, bone & abdomen. Meningitis, bacterial septicemia, pre-op. prophylaxis.

Dose
by deep intramuscular injection, or by intravenous injection over at least 2–4 minutes, or by intravenous infusion, 1 g daily; 2–4 g daily in severe infections; intramuscular doses over 1 g divided between more than one site , Neonate by intravenous infusion over 60 minutes, 20–50 mg/kg daily (max. 50 mg/kg daily) Infant and child under 50 kg, by deep intramuscular injection, or by intravenous injection over 2–4 minutes, or by intravenous infusion, 20–50 mg/kg daily; up to 80 mg/kg daily in severe infections; doses of 50 mg/kg and over by intravenous infusion only; 50 kg and over, adult dose
Uncomplicated gonorrhea, by deep intramuscular injection, 250 mg as a single dose.
Surgical prophylaxis, by deep intramuscular injection or by intravenous injection over at least 2–4 minutes, 1 g at induction; colorectal surgery, by deep intramuscular injection or by intravenous injection over at least 2–4 minutes or by intravenous infusion, 2 g at induction; intramuscular doses over 1 g divided between more than one site
Contraindications:

• Hypersensitivity to cephalosporin or Penicillin ,renal failure

Side effects:

• Nausea, vomiting, diarrhea, anorexia, abdominal pain, flatulence, skin rashes super-infection, heartburn, sore mouth, bone marrow depression.

Nursing considerations:

• I.M. injection should be deep into the body of large muscle.
• I.V. injection should be diluted.
• For stability of solution the package insert should be checked carefully.
• Dosage should be maintained for at least 2 days after symptoms of infection have disappeared (usual course is 4-14 days).