ملف كامل-متلازمة أليس في بلاد العجائب Alice in Wonderland's syndrome AIWS

Dr.AhmadDr.Ahmad مدير عام
[FONT=&quot]تعقيبا على موضوع الدكتورة [/FONT]clear[FONT=&quot] حيث لاحظت أن بعض الأفكار لم تكون واضحة و [/FONT][FONT=&quot]قد لا تتطابق الترجمة مع النص الأصلي لأني أضفت عليه مما قرأت [/FONT]


[FONT=&quot]Alice in Wonderland syndrome ( AIWS

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[FONT=&quot] (AIWS, named after the novel written by Lewis Carroll), also known as Todd's syndrome, is a disorienting neurological condition which affects human perception. Sufferers may experience micropsia, macropsia, and/or size distortion of other sensory modalities. A temporary condition, it is often associated with migraines, brain tumors, and the use of psychoactive drugs. It can also present as the initial sign of the Epstein-Barr Virus (see infectious mononucleosis). Anecdotal reports suggests that the symptoms of AIWS are fairly common in childhood, with many people growing out of them in their teens. It appears that AIWS is also a common experience at sleep onset

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[FONT=&quot]Signs and symptoms

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[FONT=&quot]Eye components are entirely normal. The AIW syndrome is a result of change in perception as opposed to the eyes themselves malfunctioning. The hallmark sign of AIWS is a migraine, and may in part be caused by the symptom itself. Using psychoactive drugs (notably dextromethorphan, LSD, Psilocybin Mushrooms or other hallucinogenic drugs) may also produce micropsia. AIWS affects the sufferer's sense of visual, sensation, touch, hearing as well as one's own body image.[/FONT]
[FONT=&quot]The most prominent and often most disturbing symptom is that of altered body image: the sufferer will find that they are confused as to the size and shape of parts of (or all of) their body.[/FONT]
[FONT=&quot]The eyes themselves are normal, but the sufferer 'sees' objects with the wrong size or shape and/or finds that perspective is incorrect. This can mean that people, cars, buildings, etc. look smaller or larger than they should be, or that distances look incorrect; for example a corridor may appear to be very long, or the ground may appear too close.[/FONT]
[FONT=&quot]In addition, some people may experience more intense and overt hallucinations, seeing things that are not there and misinterpreting events and situations in conjunction with a high fever

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Diagnosis

Because AIWS is a disturbance of perception rather than a specific physiological change to the body's systems, the diagnosis can be presumed when other, physical causes have been ruled out and if the patient presents with migraines, altered senses and complains of onset during darkness (although it can occur in light).
Delirium tremens, a serious complication of withdrawal from alcohol ( [FONT=&quot] = DTs, severe tremors and hallucinations caused by alcohol poisoning ) [/FONT], can also cause lilliputian hallucinations - visual hallucinations of small animals or people. Delirium tremens requires urgent medical treatment

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[FONT=&quot]Temporal-Lobe Epilepsy (TLE):[/FONT] [FONT=&quot] See "Temporo-Limbic Epilepsy." [/FONT]
[FONT=&quot]Temporo-Limbic Epilepsy (TLE): [/FONT] [FONT=&quot]A neurological condition involving sudden discharges of excess electrical activity in the temporal lobes and limbic system of the brain. Symptoms are hallucinatory, emotional, physical, motor, sensory and experiential in nature, but do not involve the convulsions associated with classical grand mal seizures. Also called "Temporal Lobe Epilepsy," "complex partial seizures, " "psychic seizures" and "psychomotor epilepsy." , if you wanna you can see also " biological clock," "Electro-Magnetic Sensitivity," "kundalini," "limbic system," "pineal gland" and "temporal lobe." [/FONT]


Treatment

Treatment is the same as that for other migraine prophylaxis: anticonvulsants, antidepressants, beta blockers, and calcium channel blockers, along with strict adherence to the migraine diet.


Epidemiology

No studies are available that display any correlation between age, gender or race. AIWS is thought to be relatively common among migraine sufferers.



[FONT=&quot]متلازمة أليس في بلاد العجائب [/FONT]
[FONT=&quot]تعرف أيضا بمتلازمة تود و هي حالة اضطراب في الوظيفة العصبية تؤثر على حواس الإنسان . الأشخاص المرضى قد يعانون من رؤية مستصغرة أو مستكبرة ( بصراحة ما وجدت ترجمة أفضل ) و/أو تغيرات في الحواس الأخرى و هي حالة مؤقتة , الحالة غالبا ما تترافق مع الشقيقة , أورام الدماغ , و تعاطي بعض الأدوية النفسية و لكن ممكن أن تكون كتظاهر أولي عند الإصابة بفيروس ابشتاين بار ( في داء وحيدات النوى الخمجي ) [/FONT]
[FONT=&quot]التقارير المرضية الفردية تقترح أن أعراض المتلازمة شائعة إلى حد ما بين الأطفال و خاصة أطفال الذين عانوا سابقا ( عندما كانوا صغار ) من هذه المتلازمة و يبدو أن هذه المتلازمة تشيع وقت النوم سواء في بدءه أو خلاله [/FONT]


[FONT=&quot]الأعراض و العلامات [/FONT]
[FONT=&quot]بداية بناء العين سليم تماما و مكوناتها سليمة تماما و أعراض المتلازمة تنتج عن تغير في الحواس بحيث يتعارض مع أعراض سوء في وظيفة العين ( أي أن الأعراض تؤكد على أن الأعراض العينية سببها خارج العين ) [/FONT]
[FONT=&quot]العلامة الواسمة للمتلازمة هي الشقيقة ( الصداع النصفي أو صداع نصف الرأس ) [/FONT]
[FONT=&quot]استعمال الأدوية النفسية ( خاصة [/FONT][FONT=&quot]dextromethorphan[/FONT][FONT=&quot] و [/FONT][FONT=&quot]LSD[/FONT][FONT=&quot] و [/FONT][FONT=&quot]Psilocybin Mushrooms[/FONT][FONT=&quot] و الأدوية الاخرى المهلوسة ) قد تسبب رؤية مستصغرة [/FONT]
[FONT=&quot]المتلازمة عادة ما تؤثر على الحواس كلها : البصر و الاحساس و اللمس و السمع بالإضافة لصورة جسمهم ذاتهم حيث أن العرض البارز لدى المرضى هو تغير في رؤيتهم لصورة و شك و حجم أجسامهم بالإضافة إلى التشويش في رؤية الأجسام الاخرى المحيطة , من الأعراض أيضا الخلل في تقدير المسافات سواء بالصغر أو الكبر [/FONT]
[FONT=&quot]بالاضافة لذلك هناك بعض الاسخاص يعانون من أعراض هلوسة صريحة مثل رؤية أشياء غير موجودة أصلا و حالات من سوء الفهم بالاضافة إلى حالة من التخليط مع حمى [/FONT]


[FONT=&quot]التشخيص [/FONT]
[FONT=&quot]على اعتبار أن المتلازمة هي عبارة عن مجموعة من الأعراض النفسية بغياب تبدلات عضوية في أجهزة الجسم بالتالي التشخيص سيوضع عندما يظهر هؤلاء المرضى هذه الأعراض خاصة أن يأتي المرضى مع أعراض شقيقة [/FONT]
[FONT=&quot]عادة ما يكون تبدل الحس و الشكوى لهجمة المتلازمة في الليل لكن من الممكن أن تكون في النهار[/FONT]
[FONT=&quot]يجب تفريق الحالة عن [/FONT]
1.[FONT=&quot]حالة الهذيان الارتعاشي الناجمة عن الافراط في تناول الكحول و التي تتظاهر بارتعاش خطير و هلوسة ( تتميز الهلوسة البصرية بأنها مصغرة بشكل شديد جدا ) و هذه الحالة تتطلب تدخل طبي سريع و عاجل [/FONT]
2.[FONT=&quot]صرع الفص الصدغي ( الصرع الصدغي الحوفي ) : و هي حالة حالة عصبية تتضمن انفراغ مفاجئ و شديد لشحنات عصبية ( مشابه لما يحدث في الصرع ) في الفص الصدغي و الجهاز الحوفي في الدماغ . الاعراض كثيرة تتضمن هلوسات و أعراض عاطفية و أعراض نفسية و أعراض حركية و أعراض حسية و لكن لا تتضمن نوبات اختلاج كما يحدث في داء الصرع الكبير و يدعى أيضا ( الصرع الجزئي المعقد , الصرع النفسي , الصرع الحس الحركي ) [/FONT]


[FONT=&quot]المعالجة [/FONT]
[FONT=&quot]كما في الأشكال الأخرى من الشقيقة حيث الوقاية هي الأهم : مضادات الاختلاجات , خافضات الضغط , حاصرات بيتا , حاصرات قنوات الكالسيوم , [/FONT][FONT=&quot]التزام صارم بحمية الشقيقة لفترة طويلة .[/FONT]


[FONT=&quot]الوبائيات [/FONT]
[FONT=&quot]حتى الان لا يوجد دراسات كافية عن علاقة المتلازمة بالعمر أو الجنس أو ما شابه لكن يبدو أن هناك ارتباطاً وثيقا للمتلازمة مع مرضى الشقيقة [/FONT]



[FONT=&quot]New Definition for AIWS [/FONT]
[FONT=&quot]Alice in Wonderland syndrome:[/FONT][FONT=&quot] A syndrome of distorted space, time and body image. The patient with the Alice in Wonderland syndrome has a feeling that their entire body or parts of it have been altered in shape and size. The syndrome is usually associated with visual hallucinations. The majority of patients with the syndrome have a family history of migraine headache or have overt migraine themselves.

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[FONT=&quot]تعريف آخر للمتلازمة[/FONT][FONT=&quot]: هي متلازمة يحدث فيها خلل في تقدير المسافات , الوقت و صورة الأجسام [/FONT]
[FONT=&quot]مرضى هذه المتلازمة يشعرون بتبدل في شكل و حجم أجسامهم , المتلازمة عادة ما تترافق مع اضطرابات و هلوسات بصرية و معظمهم لديه قصة عائلية للإصابة بصداع نصف الرأس أو لديهم أنفسهم صداع نصف الرأس ( شقيقة )[/FONT]
[FONT=&quot]هذه بعض الدراسات التي حصلت عليها من موقع المكتبة العالمية للطب و المعهد العالمي للصحة

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[FONT=&quot]www.pubmed.com

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[FONT=&quot]سأترجم أقوى دراستين حسب الطب المسند [/FONT][FONT=&quot]Evidance Based Medicine EBM[/FONT][FONT=&quot] وباقي الدراسات مصداقيتها ضعيفة حسب تصنيفات الــ [/FONT][FONT=&quot]EBM[/FONT][FONT=&quot] و اللي يرغب ترجمة أي دراسة أخرى أنا جاهز إن شاء الله[/FONT]

[FONT=&quot]ترجمة الدراسة الأولى : متلازمة " أليس في بلاد العجائب " المحدثة بسبب عدوى فيروس ابشتاين بار[/FONT]
[FONT=&quot]متلازمة : " أليس في بلاد العجائب " تدل على اضطراب في صورة الجسم و حجمه و شكله الظاهري بالإضافة إلى خلل في تقدير المسافات . المتلازمة عادة تترافق مع صداع نصف الرأس ( الشقيقة ) و شوهدت في العديد من الإصابات الفيروسية , شاهدنا ( أصحاب الدراسة ) طفل عمره 6 سنوات أحضر إلى قسم الإسعاف يشكو من عدة حوادث سقوط من السقف حيث أن الأجسام و الناس حوله كان يبدون له صغار جدا و بعيدون جدا . أظهر هذا الطفل عدم تغير في الوعي هذه الحوادث سببت خوفاً شديداً عند الطفل , أظهر الفحص السريري عدم وجود أي شيء مرضي عدا وجود التهاب البلعوم و اللوزتين . الدراسات المصلية أثبتت وجود عدوى بفيروس ابشتاين بار ( أضداد من نوع [/FONT][FONT=&quot]IgM[/FONT][FONT=&quot] ضد مستضدات المحفظة الفروسية ) , الأعراض لدى الطفل زالت خلال 48 ساعة و استمر لا عرضيا لمدة 4 أشهر من المعالجة , من هنا اعتبرنا أن كل طفل لديه صورة سريرية لمتلازمة " أليس في بلاد العجائب " يجب أن يخضعوا للفحوص المصلية الخاصة بكشف فيروس ابشتاين بار , التشخيص قد يمكن الأطباء النفسيين من طمأنة الأهل عن طبيعة المرض المؤقتة و السليمة [/FONT]

[FONT=&quot]ترجمة الدراسة الثانية : الاضطرابات البصرية المحرضة خلال داء الوحيدات الخمجي [/FONT]
[FONT=&quot]التوهمات البصرية التي تتصف باضطراب في الشكل و الحجم و الوضع المقلوب للأجسام و الحركة أو اللون تدعى بــ : " متلازمة أليس في بلاد العجائب " و التي نوقشت عند الأطفال المصابين بداء وحيدات النوى الخمجي و أيضاً في حالات سريرية أخرى مثل الشقيقة و الصرع و استخدام بعض الأدوية المهلوسة ... إلخ [/FONT]
[FONT=&quot]الهدف من الدراسة هو للاستقصاء عن أول وقت لتحريض الكمون البصري الحادث عند الأطفال المصابين بالمتلازمة المترافقة مع داء وحيدات النوى الخمجي . خمسة أطفال يعانون من المتلازمة مترافقة مع داء وحيدات النوى الخمجي و يعانون من اضطرابات بصرية دُرسوا خلال و بعد نوبات أعراضهم السريرية . الاضطرابات البصرية الناتجة خلال المرض تسيطر على مدى واسع ( بشكل واضح إحصائياً ) من [/FONT][FONT=&quot]p100-N145[/FONT][FONT=&quot] في كل الأطفال مقارنة بالمجموعة الشاهد . بعد عدة أسابيع , أعيدت الدراسات بعد زوال الشكوى , منذ مشاهدة نفس الموجودات المشاهدة عند مرضى الشقيقة افترضنا بشكل مسلم به أنا الآلية الفيزيولوجية المرضية للاضطرابات التي تسبب نقص ارواء دماغي بؤري عابر يمكن أن تكون المسببة نفسها في المرضين

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[FONT=&quot]Some of studies I find it in the U.S National Library of Medicine and National Institutes of Health Websites

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[FONT=&quot]The first study : [/FONT]Alice in Wonderland syndrome due to Epstein-Barr virus infection

Servicio de Pediatría. Hospital de Cabueñes. Gijón. cpmendez@infonegocio.com
The Alice in Wonderland syndrome refers to distortions in body image and in the apparent sizes, shapes, and spatial relations of objects seen. The syndrome is usually associated with migraine headaches and has also been reported in several viral infections. We report a 6-year-old boy who presented to the emergency department complaining of several episodes in which the ceiling, the objects and the people around him seemed very small and far away. The child presented no alteration in the level of consciousness. The episodes provoked great fear in the child. Physical examination revealed no abnormalities except pharyngoamygdalitis. Serologic studies (IgM antibodies to viral capsid antigen) confirmed Epstein-Barr virus infection. The child's symptoms resolved spontaneously within 48 hours and he continued to be asymptomatic after a 4 -month follow-up. We consider that all children presenting a clinical picture consistent with the Alice in Wonderland syndrome should undergo serological testing for Epstein Barr virus infection. Diagnosis would enable physicians to reassure the family of the temporary and benign nature of this alarming condition.
PMID: 11412412 [PubMed - indexed for MEDLINE]

The second study : Abnormal visual evoked potentials in children with "Alice in Wonderland" syndrome due to infectious mononucleosis.

Pediatric Neurology Unit, Division of Pediatrics, Assaf Harofeh Medical Center, Zerifin, Israel.
Visual illusions characterized by distortion of form, size, reciprocal position of objects, movement, or color, labeled as "Alice in Wonderland" syndrome, were discussed in children with infectious mononucleosis, as well as in other clinical conditions, such as migraine, epilepsy, use of certain hallucinogenic drugs, etc. The purpose of our study was to investigate for the first time visual evoked potential results in children with "Alice in Wonderland" syndrome associated with infectious mononucleosis. Five children with "Alice in Wonderland" syndrome associated with infectious mononucleosis underwent visual evoked potential studies during and after their clinical symptoms. Visual evoked potential results during the disease demonstrated statistically significant high amplitudes of P100-N145 in all children compared to the control group. A few weeks later, repeated studies after the resolution of the complaints were normal. Since the same findings can be observed in patients with migraine, we postulate that a common pathophysiologic underlying abnormality, which can cause transient focal decreased cerebral perfusion, could be involved in the disease process of these two conditions.
PMID: 10593551 [PubMed - indexed for MEDLINE]
[FONT=&quot]The Third study : [/FONT]Obligatory and facultative symptoms of the Alice in wonderland syndrome

Dipartimento di Psichiatria e Psicoterapia, Clinica di Ludwigsburg, Ludwigsburg, Germany.
The Alice in Wonderland syndrome (AIWS), as described by Todd in 1955, denotes a variety of self-experienced paroxysmal body schema disturbances (obligatory core symptoms of the AIWS) which may co-occur with depersonalization, derealization, visual illusions and disorders of the time perception (facultative symptoms of the AIWS). The name comes, of course, from Lewis Carroll's 1865 novel "Alice's Adventures in Wonderland", which is believed to have been inspired by Carroll's own migraine experiences documented as early as 1856. Recent studies of the AIWS occurring as somesthetic migraine aura indicated that the body schema disturbance of macrosomatognosia most frequently affects the head and upper extremities, paralleling the extension of their representation in the human brain. As a misapprehension commonly encountered in the medical literature, it has been suggested to define the AIWS by the presence of visual rather than somesthetic perceptual disturbances, e.g. metamorphopsia and/or visual hallucinations, but this change and broadening of Todd's definition of the AIWS turns it to a both scientifically and clinically useless concept.
PMID: 12207198 [PubMed - indexed for MEDLINE]
[FONT=&quot]The fourth study :[/FONT] Alice in Wonderland syndrome as an initial manifestation of Epstein-Barr virus infection.

Department of Pediatric Neurology, Hacettepe Children's Hospital, Hacettepe University, Faculty of Medicine, Turkey.
We present a patient with serologically confirmed Epstein-Barr virus (EBV) infection who had illusions of size, shape, and colour of objects but none of the typical symptoms and signs peculiar to infectious mononucleosis (IM) except sore throat which developed 2 weeks after the initial visual disturbances. The bizarre feelings about the images of body and objects are called the 'Alice in Wonderland syndrome' due to the similarity with Alice's dreams. The same symptomatology including visual metamorphosia is defined in patients with migraine, epilepsy, intoxication due to hallucinogenic drugs, schizophrenia, hyperpyrexia, and cerebral lesions. Alice in Wonderland syndrome has also been reported in the course of IM.
PMID: 1390519 [PubMed - indexed for MEDLINE]
[FONT=&quot]The fifth study : [/FONT]Alice in Wonderland syndrome as persistent aura of migraine and migraine disease starting

Centro de Salud A. Ponte, Ourense, España. josecorralcarames@gmail.com
INTRODUCTION: Migraine with aura in children is often described, but communications of typical aura without headache are rare, and persistent aura and Alice in Wonderland syndrome are exceptional. CASE REPORT: A 8 years-old girl who experiences during a month one to three brief episodes a day during which she relates: 'I saw things as little and remote, sometimes they moved; one day I saw my sister's books turning bigger, and another day my father getting little as a doll; sometimes my doll's leg swinged, or the blind in the window got up and down'. Later these attacks spaced out to one each to days for another two weeks. With no previous episodes of headache, these start two days after the visual distortions disappeared, with clinical features of migraine without aura. There were antecedents of migraine in maternal line, and no previous trauma, epilepsy, drug ingestion or psychiatric disorders. Clinical examination, cranial RMI, and EEG were normal. CONCLUSION: Although Alice in Wonderland syndrome was described as a migraine aura, it is usually brief, and it is exceptional that it lasts longer than a week. We think this is the first description in a pediatric patient.
PMID: 19434586 [PubMed - in process]
[FONT=&quot]The sixth study : [/FONT]Reversible palinopsia and the Alice in Wonderland syndrome associated with topiramate use in migraineurs.

Weill Medical College of Cornell University and The Methodist Hospital, Neurology, Houston, TX 77004, USA.
Two patients are reported who developed palinopsia while taking topiramate for migraine prevention which resolved or decreased in frequency or duration on lower doses, but recurred or increased in frequency or duration on higher doses. Both patients had complete resolution of palinopsia when topiramate was discontinued. A third patient is described who developed the "Alice in Wonderland" syndrome about 1 week after starting topiramate for migraine prevention with complete resolution of symptoms about 1 month after stopping. Topiramate use may cause palinopsia and may be associated with the Alice in Wonderland syndrome through an unknown mechanism.
PMID: 16643588 [PubMed - indexed for MEDLINE]


[FONT=&quot] The eight study : [/FONT]The Alice in Wonderland syndrome in juvenile migraine.

Two children are reported who had recurrent attacks of impairment of time sense, body image, and visual analysis of the environment. These occurred with a clear state of consciousness and in the absence of any evidence of an encephalitic process, seizures, drug ingestion, or psychiatric illness. Both children had recurrent headaches; one was clearly migrainous. There was a family history of migraine in both cases. These children represent examples of the Alice in Wonderland syndrome in juvenile migraine.
PMID: 440858 [PubMed - indexed for MEDLINE]

[FONT=&quot]The ninth study : [/FONT]Clinical observation and neurological outcomes in "Alice in Wonderland" syndrome.

Ten patients, aged from 3 to 10 years, who had either had attacks of perception errors of body schema and objects or had visual hallucination were enrolled from 1987 to 1990. Seven were boys and three, girls. The metamorphopsia or visual hallucination that has been named the "Alice in Wonderland syndrome" (AIWS) were the leading presentations. All the patients had preceding episodes of upper respiratory tract infection (URI) from two days to four weeks previously except for one who had had chickenpox within the immediate three days of being seen. Among these patients, six had received serological studies for Epstein-Barr (EB) virus infection. Two patients were indeed victims of acute EB virus infection as documented by positive IgM antibody against EB virus capsid antigen, the other three patients were highly suspected of having had recent EB virus infection as suggested by positive Heterophil antibody test and high IgG antibody titer against EB virus capsid antigen (1:320X). The duration of perception disorder ranged from four days to three months. All cases recovered completely, without sequelae. It is emphasized that any young children who present as acute episodes of AIWS should undergo examination for EB virus infection. The neurological outcome of AIWS seems to be good.
PMID: 1325095 [PubMed - indexed for MEDLINE]
[FONT=&quot]The tenth study : [/FONT]Abnormal magnetic resonance imaging in a child with Alice in Wonderland syndrome following Epstein-Barr virus infection

Department of Pediatrics, Iwate Medical University, Morioka, Iwate.
Characteristic pathologic changes of cranial computed tomography (CT) and magnetic resonance imaging (MRI) have never been reported in "Alice in Wonderland" syndrome (AIWS) caused by Epstein-Barr (EB) virus infection. We present here a 10-year-old girl with AIWS with an abnormal MR finding. During the course of serologically confirmed EB virus encephalopathy, she had distortion of the body image, visual hallucinations and depersonalization characteristic of AIWS. MRI demonstrated transient T2 prolongation and swelling of the cerebral cortex, especially at the bilateral temporal lobes, bilateral cingulate gyrus, right upper frontal gyrus, bilateral caudate nucleus, and bilateral putamen, whereas CT showed no abnormalities. Transient MRI lesions were occasionally reported in patients with EB virus encephalopathy/encephalitis who presented visual illusions and psychotic reactions, although the diagnosis of AIWS was not described. We consider that any patient with symptoms of AIWS should have MRI because the abnormal MRI findings may disappear in a short period.
PMID: 12134688 [PubMed - indexed for MEDLINE]
[FONT=&quot]The eleventh study : [/FONT]Metamorphopsia of the Alice in Wonderland-syndrome

St. Clara Ziekenhuis, afd. Kindergeneeskunde, Rotterdam.
A boy aged 9 had had two years previously and again since a few weeks complaints of observing objects with distortion and reduction in size. He was known to suffer from asthma for which he received beclomethasone in a low dosage. Physical and supplementary examinations revealed no abnormalities. The condition was diagnosed as 'metamorphopsia'.
PMID: 10065245 [PubMed - indexed for MEDLINE]


[FONT=&quot]The twelfth study : [/FONT]Alice in Wonderland' syndrome and Lilliputian hallucinations in a patient with a substance-related disorder.

Department of Psychiatry, Gifu University School of Medicine, Gifu, Japan. takaoka@cc.gifu-u.ac.jp
The present paper describes a patient who exhibited 'Alice in Wonderland' (AIW) syndrome as well as Lilliputian hallucinations. The patient regularly consumed a cough syrup that contained dihydrocodein phosphate and dl-methylephedrine hydrochloride over 3 years. At the age of 46, he developed AIW syndrome. The patient ingested a large dose of triazolam and exhibited delirium. Even after the disappearance of symptoms associated with AIW syndrome and delirium, the patient continued to experience Lilliputian hallucinations. We believe that these hallucinations were caused by some of the components of the cough syrup.
PMID: 9885400 [PubMed - indexed for MEDLINE]
[FONT=&quot]The thirteenth study : [/FONT]Alice in Wonderland" syndrome as a presenting symptom of infectious mononucleosis in children: a description of three affected young people.

Three cases of "Alice in Wonderland" syndrome (metamorphopsia) are presented and described as a presenting symptom of infectious mononucleosis in a preadolescent male and in two late teenage females. In each instance, the classical infectious mononucleosis symptoms and diagnosis followed the onset of visual aberration. Thorough physical and blood examination of patients who present with such a syndrome must be undertaken before these symptoms are ascribed to psychiatric abnormalities. It is emphasized that infectious mononucleosis is a diffuse disorder, often associated with encephalopathies, which may include visual imbalance symptoms.
PMID: 832438 [PubMed - indexed for MEDLINE]
[FONT=&quot]The fourteenth study : [/FONT]Literary neurologic syndromes. Alice in Wonderland.

Department of Neurology, Houston Veteran's Affairs Medical Center, TX.
Many neurologic syndromes are named for literary characters. For example, the "Alice in Wonderland" syndrome of altered body perceptions, usually caused by migrainous ischemia, is so called because of the resemblance of its symptoms to the fluctuations in size and shape that plague the main character in Lewis Carroll's 1865 novel Alice in Wonderland. The medical symptoms of distorted body images match the literary description so precisely that illustrations from the original book depict them very accurately. Because Lewis Carroll suffered from classic migraine headaches, scholars have speculated that he may have experienced this syndrome himself.
PMID: 2039389 [PubMed - indexed for MEDLINE]

التعليقات

  • تم تعديل 2009/07/08
    شكرا جزيلا ..................thank you so much
  • تم تعديل 2009/07/08
    شكرل لكم دكتور على الايض2اح الكاف الواف بارك الله بكم --يستطيع الطالبالاستعانة به من بعد اذنكم
  • Dr.AhmadDr.Ahmad مدير عام
    تم تعديل 2009/07/09
    شكرا عاشقة العلوم و حكيم نهاد على المرور
    أكيد حكيم نهاد الاستفادة متاحة لكل الناس فالغاية من الموقع نشر العلم و المعرفة
  • تم تعديل 2009/07/11
    شـكــ وبارك الله فيك ـــرا لك ... لك مني أجمل تحية .
  • jwanitojwanito عضو مميز
    تم تعديل 2009/08/20
    شكرا دكتور
  • تم تعديل 2009/08/20
    [align=center]مشكور دكتور أحمد
    الله يعطيك العافية[/align]
  • Dr.AhmadDr.Ahmad مدير عام
    تم تعديل 2009/08/21
    اهلا حكيم ريان و حكيم محمد و ان شاء الله تكون الفائدة تحققت
  • الريــمالريــم عضو جديد
    تم تعديل 2012/04/20
    شكراً جزيلاً ..

    لكن اتمنى ان تفيدوني بكتب او مراجع يمكنني الرجوع اليها للتعمق اكثر في ذلك .. لاني اجري بحث عن هذه المتلازمة ...!؟
  • Dr.AhmadDr.Ahmad مدير عام
    تم تعديل 2012/04/21
    اهلا و سهلا أخت الريم

    من الصعب إيجاد كتب لهذه المتلازمة ... و حقيقة بعد البحث و العناء حتى استطعت تجميع هذا الموضوع