موقع العيادة السورية هو موقع طبي ثقافي يهتم باغناء المحتوى الطبي العربي على الانترنت.
يتألف الموقع من مجموعة غنية من الأقسام كالمكتبة الطبية, الموسوعات الطبية, المنتديات الطبية, وغيرها.
Description
A cytotoxic antibiotic.
Indications
Paediatric cancers.
Effects on oral and dental structures
Dactinomycin causes bone marrow suppression with an accompanying
thrombocytopenia and agranulocytosis. Bone marrow suppression
can lead to troublesome oral ulceration, exacerbation of an
existing periodontal condition, and rapid spread of any residual (e.g.
periapical) infections.
Effects on patient management
The effect of dactinomycin on the bone marrow is transient and
routine dental treatment is best avoided until the white blood cells
and platelet counts start to recover. If emergency dental treatment
such as an extraction is required then antibiotic cover may be necessary
depending on the degree of myelosuppression. If the platelet
count is low (100,000) then the socket should be packed andsutured. Persistent bleeding may require a platelet transfusion.
Patients on chemotherapeutic agents such as dactinomycin often
neglect their oral hygiene and thus there could be an increase in both
caries and periodontal disease. If time permits, patients about to go
on chemotherapy should have a dental check up and any potential
areas of infection should be treated. Similarly, to reduce the mucosal
irritation (sensitivity) that often accompanies chemotherapy, it is
advisable to smooth over rough cusps or restorations.
Drug interactions
None of any dental significance.