Danazol

Description
An inhibitor of pituitary gonadotrophin.
Indications
Endometriosis, menorrhagia, severe cyclical mastalgia, benign breast cysts and gynaecomastia.
Effects on oral and dental structures
A rare unwanted effect of danazol is leucopenia and thrombocytopenia.
Both can affect the expression of periodontal disease and also exacerbate gingival bleeding.
Effects on patient management
Danazol-induced thrombocytopenia can cause problems with prolonged bleeding following a dental surgical procedure. Always check patients susceptibility to prolonged bleeding or bruising. If prolonged bleeding does occur and fails to respond to local measures, then haemostasis can only be achieved with a platelet transfusion.
Drug interactions
None of any dental significance.