INSTRUCTION Examine this patient's eyes. Examine this patient's fundus. SALIENT FEATURES History · Usually no ocular symptoms. · History of hypertension. Examination (Fig. 77) · Arteriovenous nipping. · Arteriolar narrowing. · Macular star. · Flame-shaped and blot haemorrhages. · Cottonwool exudates. · Papilloedema may or may not be present. Proceed as follows: Tell the examiner that you would like to: · Check the blood pressure. · Examine the urine for proteinuria. · Examine the heart for left ventricular hypertrophy. DIAGNOSIS This patient has flame-shaped haemorrhages with a macular star (lesions) due to hypertension (aetiology). ADVANCED-LEVEL QUESTIONS How would you grade hypertensive retinopathy? Keith-Wagner-Barker classification (Am J Med Sci 1939; 197: 33243): · Stage I - arteriolar narrowing. · Stage Il - irregular calibre of arterioles. · Stage III - cottonwool exudates; flame and blot haemorrhages, retinal oedema. · Stage IV - papilloedema. Note. Subsequent studies have shown that the clinical features and prognosis of patients with stage III and stage IV disease were similar whether or not papillo-edema was present; consequently the terms 'malignant' and 'accelerated' can be used interchangeably (BMJ 1986; 292: 235-7; Q J Med 1993; 86: 485-93). Instead, 'hypertensive crisis' is used to refer to the syndrome of raised blood pressure com-plicated by end-organ damage (e.g. stroke, renal failure, myocardial ischaemia or infarction, stage Ill or IV hypertensive retinopathy). Mention some causes of cottonwool spots (Lancet 1965: i.' 303). · HIV infection per se. · Anaemias. · Infective endocarditis. · Leukaemias. · Diabetic retinopathy (see pp 518-23). Mention a few causes of hypertension. · In 90% of cases it is essential hypertension with no underlying cause, and this may represent the 'normal' spread. · In 10% of cases there is an underlying cause: -renal causes : renal artery stenosis, polycystic kidneys, chronic glomerulo-nephritis, polyarteritis nodosa, chronic pyelonephritis. Endocrine causes: Cushing's syndrome, Conn's syndrome, phaeochromocytoma, acromegaly, diabetes mellitus. - Eclampsia and pre-eclamptic toxaemia of pregnancy. - Coarctation of the aorta. How would you investigate a patient with hypertension? · Urine for protein, glucose, casts. · Mid-stream urine for microscopy and culture. · Urea and electrolytes, fasting lipids. · CXR. · ECG. · Urine catecholamines. · Intravenous pyelography. · Renal artery digital subtraction angiography (DSA). How would you treat hypertension ? · Salt restriction. · Drug therapy. · First line (BMJ 1990; 301: 1172): -In women and smokers - bendrofiumethiazide (bendrofluazide). -In non-smoking men - beta-blockers. · Advise the patient to stop smoking. Sir C.T. Dollery, was Dean of the Royal Postgraduate Medical School, Hammersmith Hospital, London; his interests include clinical pharmacology, hypertension and medical education. John Swales, contemporary Professor of Medicine, Leicester; his chief interest is hypertension. James C. Petrie, Professor and Head of Medicine and Therapeutics, Aberdeen; his interests included hypertension and cardiovascular prevention. He was also the President of the Royal College of Physicians of Edinburgh.