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Pronunciation |
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(yo
HIM
bine) |
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U.S. Brand
Names |
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Aphrodyne™; Dayto Himbin®;
Yocon®; Yohimex™ |
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Generic
Available |
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Yes |
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Synonyms |
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Yohimbine Hydrochloride |
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Pharmacological Index |
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Miscellaneous Product |
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|
Use |
|
Unlabeled uses: Treat SSRI-induced sexual dysfunction; weight loss;
impotence; sympathicolytic and mydriatic; may have activity as an
aphrodisiac |
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Contraindications |
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Renal disease, hypersensitivity to yohimbine |
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Warnings/Precautions |
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Do not use in pregnancy; do not use in children; not for use in geriatric,
psychiatric, or cardio-renal patients with a history of gastric or duodenal
ulcer; generally not for use in females. Should not be used in kidney disease or
psychiatric disorders; can cause high blood pressure and anxiety, tachycardia,
nausea, or vomiting. |
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Adverse
Reactions |
|
Cardiovascular: Tachycardia, hypertension, hypotension (orthostatic),
flushing
Central nervous system: Anxiety, mania, hallucinations, irritability,
dizziness, psychosis, insomnia, headache, panic attacks
Gastrointestinal: Nausea, vomiting, anorexia, salivation
Neuromuscular & skeletal: Tremors
Miscellaneous: Antidiuretic action, diaphoresis |
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Drug
Interactions |
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CYP2D6 and 3A3/4 enzyme substrate; CYP2D6 enzyme inhibitor
|
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Mechanism of
Action |
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Derived from the bark of the yohimbe tree ( Corynanthe yohimbe), this
indole alkaloid produces a presynaptic alpha2-adrenergic blockade.
Peripheral autonomic effect is to increase cholinergic and decrease adrenergic
activity; yohimbine exerts a stimulating effect on the mood and a mild
antidiuretic effect. |
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Pharmacodynamics/Kinetics |
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Absorption: Oral: 33%
Half-life: 0.6 hour |
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Usual Dosage |
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Adults: Oral:
Orthostatic hypotension: Doses of 12.5 mg/day have been utilized; however,
more research is necessary |
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Dental Health: Local
Anesthetic/Vasoconstrictor
Precautions |
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No information available to require special precautions |
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Dental Health:
Effects on Dental Treatment |
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No effects or complications reported |
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Patient
Information |
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Considered unsafe |
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Dosage Forms |
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Tablet, as hydrochloride: 5.4
mg |
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