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Licorice
Uva Ursi
  Interactions with supplements
Cysteine
Dehydroepiandrosterone (DHEA)
Look Up > Drugs > Sulfacetamide Sodium and Prednisolone
Sulfacetamide Sodium and Prednisolone
Pronunciation
U.S. Brand Names
Generic Available
Synonyms
Pharmacological Index
Use
Pregnancy Risk Factor
Adverse Reactions
Drug Interactions
Mechanism of Action
Usual Dosage
Dental Health: Local Anesthetic/Vasoconstrictor Precautions
Dental Health: Effects on Dental Treatment
Patient Information
Nursing Implications
Dosage Forms

Pronunciation
(sul fa SEE ta mide SOW dee um & pred NIS oh lone)

U.S. Brand Names
AK-Cide® Ophthalmic; Blephamide® Ophthalmic; Cetapred® Ophthalmic; Isopto® Cetapred® Ophthalmic; Metimyd® Ophthalmic; Vasocidin® Ophthalmic

Generic Available

Yes


Synonyms
prednisolone and sulfacetamide

Pharmacological Index

Antibiotic/Corticosteroid, Ophthalmic


Use

Steroid-responsive inflammatory ocular conditions where infection is present or there is a risk of infection; ophthalmic suspension may be used as an otic preparation


Pregnancy Risk Factor

C


Adverse Reactions

1% to 10%: Local: Burning, stinging

<1%:

Central nervous system: Vertigo, seizures, psychoses, pseudotumor cerebri, headache

Dermatologic: Stevens-Johnson syndrome, skin atrophy

Endocrine & metabolic: Cushing's syndrome, pituitary-adrenal axis suppression, growth suppression

Gastrointestinal: Peptic ulcer, nausea, vomiting

Neuromuscular & skeletal: Muscle weakness, osteoporosis, fractures

Ocular: Cataracts, glaucoma


Drug Interactions

Decreased effect: Silver, gentamicin, vaccines, toxoids


Mechanism of Action

Interferes with bacterial growth by inhibiting bacterial folic acid synthesis through competitive antagonism of PABA; decreases inflammation by suppression of migration of polymorphonuclear leukocytes and reversal of increased capillary permeability; suppresses the immune system by reducing activity and volume of the lymphatic system


Usual Dosage

Children >2 months and Adults: Ophthalmic:

Solution: Instill 1-3 drops every 2-3 hours while awake


Dental Health: Local Anesthetic/Vasoconstrictor Precautions

No information available to require special precautions


Dental Health: Effects on Dental Treatment

No effects or complications reported


Patient Information

Eye drops will burn upon instillation; wait at least 10 minutes before using another eye preparation; may sting eyes when first applied; do not touch container to eye; ointment will cause blurred vision; notify physician if condition does not improve in 3-4 days; may cause sensitivity to sunlight


Nursing Implications

Shake ophthalmic suspension before using


Dosage Forms

Ointment, ophthalmic:

AK-Cide®, Metimyd®, Vasocidin®: Sulfacetamide sodium 10% and prednisolone acetate 0.5% (3.5 g)

Blephamide®: Sulfacetamide sodium 10% and prednisolone acetate 0.2% (3.5 g)

Cetapred®: Sulfacetamide sodium 10% and prednisolone acetate 0.25% (3.5 g)

Suspension, ophthalmic: Sulfacetamide sodium 10% and prednisolone sodium phosphate 0.25% (5 mL)

Suspension, ophthalmic:

AK-Cide®, Metimyd®: Sulfacetamide sodium 10% and prednisolone acetate 0.5% (5 mL)

Blephamide®: Sulfacetamide sodium 10% and prednisolone acetate 0.2% (2.5 mL, 5 mL, 10 mL)

Isopto® Cetapred®: Sulfacetamide sodium 10% and prednisolone acetate 0.25% (5 mL, 15 mL)

Vasocidin®: Sulfacetamide sodium 10% and prednisolone sodium phosphate: 0.25% (5 mL, 10 mL)


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