Yes

Theophylline Derivative

Bronchodilator in symptomatic treatment of asthma and reversible bronchospasm

C

Uncommon with theophylline levels <20 mcg/mL

Cardiovascular: Tachycardia

Central nervous system: Nervousness, restlessness

Gastrointestinal: Nausea, vomiting

<1%:

Central nervous system: Insomnia, irritability, seizures

Dermatologic: Skin rash

Gastrointestinal: Gastric irritation

Neuromuscular & skeletal: Tremor

Miscellaneous: Allergic reactions

Oral:

Children 9-16 years and Adult smokers: 4.7 mg/kg/dose every 6 hours

Adults: 4.7 mg/kg every 8 hours; sustained release: administer every 12 hours

Should be administered with water 1 hour before or 2 hours after meals

No information available to require special precautions

Do not prescribe any erythromycin product to patients taking theophylline products. Erythromycin will delay the normal metabolic inactivation of theophyllines leading to increased blood levels; this has resulted in nausea, vomiting and CNS restlessness

Oral preparations should be taken with a full glass of water; avoid drinking or eating large quantities of caffeine-containing beverages or food; take at regular intervals; take with food if GI upset occurs; notify physician if nausea, vomiting, insomnia, nervousness, irritability, palpitations, seizures occur; do not change from one brand to another without consulting physician and pharmacist; do not change doses without consulting your physician

Administer oral administration around-the-clock rather than 4 times/day, 3 times/day, etc, (ie, 12-6-12-6, not 9-1-5-9) to promote less variation in peak and trough serum levels; do not crush sustained release drug products; encourage patient to drink adequate fluids (2 L/day) to decrease mucous viscosity in airways

Monitor heart rate, vital signs, serum concentrations, CNS effects (insomnia, irritability); respiratory rate (COPD patients often have resting controlled respiratory rates in the low 20s)

Elixir: 100 mg/5 mL (5 mL, 10 mL, 473 mL)

Syrup: 50 mg/5 mL (473 mL)

Tablet: 100 mg, 200 mg

Sustained release: 400 mg, 600 mg