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Pronunciation |
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(nee
oh MYE sin & pol i MIKS in
bee) |
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U.S. Brand
Names |
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Neosporin® Cream [OTC]; Neosporin®
G.U.
Irrigant |
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Generic
Available |
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Yes |
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Synonyms |
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Polymyxin B and Neomycin |
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Pharmacological Index |
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Antibiotic, Topical |
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Use |
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Short-term as a continuous irrigant or rinse in the urinary bladder to
prevent bacteriuria and gram-negative rod septicemia associated with the use of
indwelling catheters; to help prevent infection in minor cuts, scrapes, and
burns |
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Pregnancy Risk
Factor |
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C/D (for G.U. irrigant) |
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Contraindications |
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Hypersensitivity to neomycin or polymyxin B or any component; ophthalmic use
for topical cream |
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Adverse
Reactions |
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1% to 10%:
Genitourinary: Bladder irritation
Local: Burning
Neuromuscular & skeletal: Neuromuscular blockade
Otic: Ototoxicity
Renal: Nephrotoxicity |
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Drug
Interactions |
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No data reported |
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Stability |
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Store irrigation solution in refrigerator; aseptic prepared dilutions (1 mL/1
L) should be stored in the refrigerator and discarded after 48
hours |
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Mechanism of
Action |
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Refer to individual monographs |
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Pharmacodynamics/Kinetics |
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Absorption: Topical: Not absorbed following application to intact skin;
absorbed through denuded or abraded skin, peritoneum, wounds, or
ulcers |
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Usual Dosage |
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Children and Adults:
Topical: Apply cream 1-4 times/day to affected area |
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Administration |
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Bladder irrigant: Do not inject irrigant solution; concentrated irrigant
solution must be diluted in 1 L normal saline before administration; connect
irrigation container to the inflow lumen of a 3-way catheter to permit
continuous irrigation of the urinary bladder |
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Mental Health: Effects
on Mental Status |
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None reported |
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Mental Health:
Effects on Psychiatric
Treatment |
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None reported |
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Dental Health: Local
Anesthetic/Vasoconstrictor
Precautions |
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No information available to require special precautions |
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Dental Health:
Effects on Dental Treatment |
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No effects or complications reported |
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Patient
Information |
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See individual agents. Pregnancy/breast-feeding precautions: Inform
prescriber if you are or intend to be pregnant. Consult prescriber if
breast-feeding. |
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Nursing
Implications |
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Monitor urinalysis |
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Dosage Forms |
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Cream: Neomycin sulfate 3.5 mg and polymyxin B sulfate 10,000 units per g
(0.94 g, 15 g)
Solution, irrigant: Neomycin sulfate 40 mg and polymyxin B sulfate 200,000
units per mL (1 mL, 20 mL) |
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