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Pronunciation |
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(meth
oh KAR ba mole & AS pir
in) |
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U.S. Brand
Names |
|
Robaxisal® |
|
|
Generic
Available |
|
Yes |
|
|
Synonyms |
|
Aspirin and Methocarbamol |
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|
Pharmacological Index |
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Skeletal Muscle Relaxant |
|
|
Use |
|
Dental: Treatment of muscle spasm associated with acute temporomandibular
joint pain
Medical: Adjunct to rest, physical therapy, and other measures for the relief
of discomfort associated with acute, painful musculoskeletal disorders
|
|
|
Pregnancy Risk
Factor |
|
C/D (if full-dose aspirin in 3rd trimester) |
|
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Contraindications |
|
Methocarbamol: Renal impairment, hypersensitivity to methocarbamol or any
component
Aspirin: Bleeding disorders (factor VII or IX deficiencies), hypersensitivity
to salicylates or other NSAIDs, tartrazine dye and asthma |
|
|
Warnings/Precautions |
|
Use aspirin with caution in patients with platelet and bleeding disorders,
renal dysfunction, erosive gastritis, or peptic ulcer disease, previous
nonreaction does not guarantee future safe taking of medication; do not use
aspirin in children <16 years of age for chickenpox or flu symptoms due to
the association with Reye's syndrome
Elderly are a high-risk population for adverse effects from nonsteroidal
anti-inflammatory agents. As much as 60% of elderly with GI complications to
NSAIDs can develop peptic ulceration and/or hemorrhage asymptomatically. Also,
concomitant disease and drug use contribute to the risk for GI adverse effects.
Use lowest effective dose for shortest period possible. Consider renal function
decline with age. Use with caution in patients with history of asthma
|
|
|
Adverse
Reactions |
|
Methocarbamol: >10%: Central nervous system: Drowsiness, dizziness,
lightheadedness
Aspirin:
>10%: Gastrointestinal: Nausea, vomiting, dyspepsia, epigastric
discomfort, heartburn, stomach pains
1% to 10%: Gastrointestinal: Ulceration |
|
|
Drug
Interactions |
|
Methocarbamol: Increased effect/toxicity with CNS depressants
Aspirin: Concomitant use of aspirin may result in possible decreased serum
concentration of NSAIDs; aspirin may antagonize effects of probenecid; aspirin
may increase methotrexate serum levels. Aspirin may displace valproic acid from
binding sites which can result in toxicity; warfarin and aspirin result in
increased bleeding; NSAIDs and aspirin result in increased GI adverse effects.
|
|
|
Mechanism of
Action |
|
Causes skeletal muscle relaxation by reducing the transmission of impulses
from the spinal cord to skeletal muscle |
|
|
Pharmacodynamics/Kinetics |
|
Methocarbamol:
Absorption: Rapid
Onset of muscle relaxation: Oral: Within 30 minutes
Time to peak serum concentration: Oral: ~2 hours
Serum half-life: 1-2 hours
Aspirin:
Absorption: Rapid
Time to peak serum concentration: ~1-2 hours
Serum half-life:
Parent drug: 15-20 minutes
Salicylates (dose-dependent): From 3 hours at lower doses (300-600 mg), to
5-6 hours (after 1 g) to 10 hours with higher doses |
|
|
Usual Dosage |
|
Children >12 years and Adults: Oral: 2 tablets 4
times/day |
|
|
Dietary
Considerations |
|
Food decreases rate but not extent of absorption (oral) |
|
|
Dental Health: Local
Anesthetic/Vasoconstrictor
Precautions |
|
No information available to require special precautions |
|
|
Dental Health:
Effects on Dental Treatment |
|
Use with caution in patients with platelet and bleeding disorders, renal
dysfunction, erosive gastritis, or peptic ulcer disease, previous nonreaction
does not guarantee future safe taking of medication; use with caution in
impaired hepatic function; do not use aspirin in children <16 years of age
for chickenpox or flu symptoms due to the association with Reye's syndrome
Elderly are a high-risk population for adverse effects from nonsteroidal
anti-inflammatory agents. As much as 60% of elderly with GI complications to
NSAIDs can develop peptic ulceration and/or hemorrhage asymptomatically. Also,
concomitant disease and drug use contribute to the risk for GI adverse effects.
Use lowest effective dose for shortest period possible. Consider renal function
decline with age. Use with caution in patients with history of asthma
|
|
|
Patient
Information |
|
See individual agents. Pregnancy/breast-feeding precautions: Inform
prescriber if you are or intend to be pregnant. Consult prescriber if
breast-feeding. |
|
|
Dosage Forms |
|
Tablet: Methocarbamol 400 mg and aspirin 325
mg |
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