|
Pronunciation |
|
(me
TAKS a
lone) |
|
|
U.S. Brand
Names |
|
Skelaxin® |
|
|
Generic
Available |
|
No |
|
|
Pharmacological Index |
|
Skeletal Muscle Relaxant |
|
|
Use |
|
Relief of discomfort associated with acute, painful musculoskeletal
conditions |
|
|
Pregnancy Risk
Factor |
|
C |
|
|
Contraindications |
|
Impaired hepatic or renal function, known hypersensitivity to metaxalone,
history of drug-induced hemolytic anemias or other anemias |
|
|
Warnings/Precautions |
|
Use with caution in patients with impaired hepatic
function |
|
|
Adverse
Reactions |
|
>10%:
Gastrointestinal: Nausea, vomiting, stomach cramps
Central nervous system: Paradoxical stimulation, headache, drowsiness,
dizziness
<1%:
Dermatologic: Allergic dermatitis
Hematologic: Leukopenia, hemolytic anemia
Hepatic: Hepatotoxicity
Miscellaneous: Anaphylaxis |
|
|
Overdosage/Toxicology |
|
Signs and symptoms: No major toxicities have been reported
|
|
|
Drug
Interactions |
|
Increased effect of alcohol, CNS depressants |
|
|
Mechanism of
Action |
|
Does not have a direct effect on skeletal muscle; most of its therapeutic
effect comes from actions on the central nervous system |
|
|
Pharmacodynamics/Kinetics |
|
Onset of action: ~1 hour
Duration: ~4-6 hours
Half-life: 2-3 hours
Elimination: In urine as metabolites |
|
|
Usual Dosage |
|
Children >12 years and Adults: Oral: 800 mg 3-4
times/day |
|
|
Test
Interactions |
|
False-positive Benedict's test |
|
|
Mental Health: Effects
on Mental Status |
|
Drowsiness and dizziness are common; may cause paradoxical
stimulation |
|
|
Mental Health:
Effects on Psychiatric
Treatment |
|
May cause leukopenia; use caution with clozapine and carbamazepine;
concurrent use with psychotropics may produce additive
sedation |
|
|
Dental Health: Local
Anesthetic/Vasoconstrictor
Precautions |
|
No information available to require special precautions |
|
|
Dental Health:
Effects on Dental Treatment |
|
No effects or complications reported |
|
|
Patient
Information |
|
Avoid alcohol and other CNS depressants; may cause drowsiness, impairment of
judgment, or coordination; notify physician of dark urine, pale stools,
yellowing of eyes, severe nausea, vomiting, or abdominal
pain |
|
|
Nursing
Implications |
|
Raise bed rails, institute safety measures, assist with
ambulation |
|
|
Dosage Forms |
|
Tablet: 400 mg |
|
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|