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Pronunciation |
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(lin
koe MYE
sin) |
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U.S. Brand
Names |
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Lincocin® Injection; Lincocin®
Oral; Lincorex®
Injection |
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Generic
Available |
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No |
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Synonyms |
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Lincomycin Hydrochloride |
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Pharmacological Index |
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Antibiotic, Macrolide |
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Use |
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Treatment of susceptible bacterial infections, mainly those caused by
streptococci and staphylococci resistant to other agents |
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Pregnancy Risk
Factor |
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B |
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Contraindications |
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Minor bacterial infections or viral infections; hypersensitivity to
lincomycin or any component or clindamycin |
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Adverse
Reactions |
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1% to 10%: Gastrointestinal: Nausea, vomiting, diarrhea |
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Drug
Interactions |
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Decreased effect with erythromycin
Increased activity/toxicity of neuromuscular blocking agents
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Mechanism of
Action |
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Lincosamide antibiotic which was isolated from a strain of Streptomyces
lincolnensis; lincomycin, like clindamycin, inhibits bacterial protein
synthesis by specifically binding on the 50S subunit and affecting the process
of peptide chain initiation. Other macrolide antibiotics (erythromycin) also
bind to the 50S subunit. Since only one molecule of antibiotic can bind to a
single ribosome, the concomitant use of erythromycin and lincomycin is not
recommended. |
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Pharmacodynamics/Kinetics |
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Absorption: Oral: ~20% to 30%
Serum half-life, elimination: 2-11.5 hours
Time to peak serum concentration:
Oral: 2-4 hours
I.M.: 1 hour |
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Usual Dosage |
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Children >1 month:
Oral: 30-60 mg/kg/day in divided doses every 8 hours
I.M.: 10 mg/kg every 8-12 hours
I.V.: 10-20 mg/kg/day in divided doses every 8-12 hours
Adults:
Oral: 500 mg every 6-8 hours
I.M.: 600 mg every 12-24 hours
I.V.: 600-1 g every 8-12 hours up to 8 g/day
Dosing interval in renal impairment:
Clcr 10-50 mL/minute: Administer every 6-12 hours
Clcr <10 mL/minute: Administer every 12 hours
Dosing adjustment in hepatic impairment: Reductions are indicated
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Dietary
Considerations |
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Decreased absorption with food; should be administered on empty stomach with
water |
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Administration |
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Administer oral dosage form with a full glass of water to minimize esophageal
ulceration; administer around-the-clock to promote less variation in peak and
trough serum levels |
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Mental Health: Effects
on Mental Status |
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May cause dizziness |
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Mental Health:
Effects on Psychiatric
Treatment |
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May cause granulocytopenia; use caution with clozapine and
carbamazepine |
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Dental Health: Local
Anesthetic/Vasoconstrictor
Precautions |
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No information available to require special precautions |
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Dental Health:
Effects on Dental Treatment |
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No effects or complications reported |
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Patient
Information |
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Report any severe diarrhea immediately and do not take antidiarrheal
medication; take each oral dose with a full glass of water; finish all
medication; do not skip doses; store capsules in a light-proof
container |
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Nursing
Implications |
|
Administer oral dosage form with a full glass of water to minimize esophageal
ulceration; administer around-the-clock to promote less variation in peak and
trough serum levels |
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Dosage Forms |
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Lincomycin hydrochloride:
Injection: 300 mg/mL (2 mL, 10 mL)
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