As with all drugs which may affect hemostasis, bleeding is associated with
clopidogrel. Hemorrhage may occur at virtually any site. Risk is dependent on
multiple variables, including the concurrent use of multiple agents which alter
hemostasis and patient susceptibility.
Gastrointestinal: The overall incidence of gastrointestinal events (including
abdominal pain, vomiting, dyspepsia, gastritis and constipation) has been
documented to be 27.1% compared to 29.8% in patients receiving aspirin.
2.5% to 10%:
Cardiovascular: Chest pain (8.3%), edema (4.1%), hypertension (4.3%)
Central nervous system: Headache (7.6%), dizziness (6.2%), depression (3.6%),
fatigue (3.3%), general pain (6.4%)
Dermatologic: Rash (4.2%), pruritus (3.3%)
Endocrine and metabolic: Hypercholesterolemia (4.0%)
Gastrointestinal: Abdominal pain (5.6%), dyspepsia (5.2%), diarrhea (4.5%),
nausea (3.4%), hemorrhage (2%)
Genitourinary: Urinary tract infection (3.1%)
Hematologic: Purpura (5.3%), epistaxis (2.9%)
Hepatic: Liver function test abnormalities (<3%; discontinued in 0.11%)
Neuromuscular and skeletal: Arthralgia (6.3%), back pain (5.8%)
Respiratory: Dyspnea (4.5%), rhinitis (4.2%), bronchitis (3.7%), coughing
(3.1%), upper respiratory infections (8.7%)
Miscellaneous: Flu-like syndrome (7.5%)
1% to 2.5%: Syncope, palpitation, weakness, cardiac failure, leg cramps,
neuralgia, paresthesia, vertigo, atrial fibrillation, hyperuricemia, gout,
arthritis, GI hemorrhage, hematoma, anxiety, insomnia, anemia, eczema, cystitis,
cataract, conjunctivitis
<1% (Limited to important or life-threatening symptoms): Allergic
reaction, angioedema, bronchospasm, anaphylactoid reaction, ischemic necrosis,
bilirubinemia, fatty liver, hematuria, hemoptysis, intracranial hemorrhage
(0.4%), retroperitoneal bleeding, hepatitis, ocular hemorrhage, pulmonary
hemorrhage, purpura, thrombocytopenia, aplastic anemia, hypochromic anemia,
menorrhagia, hemothorax, bullous eruption, maculopapular rash, urticaria,
agranulocytosis, granulocytopenia, leukopenia, neutropenia (0.05%), thrombotic
thrombocytopenic purpura