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Pronunciation |
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(BEN
zoe il peer OKS
ide) |
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U.S. Brand
Names |
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Advanced Formula Oxy® Sensitive Gel
[OTC]; Ambi 10®[OTC]; Ben-Aqua®[OTC]; Benoxyl®;
Benzac AC® Gel; Benzac AC® Wash; Benzac W® Gel;
Benzac W® Wash; 5-Benzagel®; 10-Benzagel®;
Benzashave® Cream; BlemErase® Lotion [OTC]; Brevoxyl®
Gel; Clear By Design® Gel [OTC]; Clearsil® Maximum Strength
[OTC]; Del Aqua-5® Gel; Del Aqua-10® Gel; Desquam-E™
Gel; Desquam-X® Gel; Desquam-X® Wash; Dryox® Gel
[OTC]; Dryox® Wash [OTC]; Exact® Cream [OTC]; Fostex®
10% BPO Gel [OTC]; Fostex® 10% Wash [OTC]; Fostex® Bar [OTC];
Loroxide®[OTC]; Neutrogena® Acne Mask [OTC]; Oxy-5®
Advanced Formula for Sensitive Skin
[OTC]; Oxy-5® Tinted [OTC]; Oxy-10® Advanced Formula for
Sensitive Skin
[OTC]; Oxy 10® Wash [OTC]; PanOxyl®-AQ; PanOxyl® Bar
[OTC]; Perfectoderm® Gel [OTC]; Peroxin A5®; Peroxin
A10®; Persa-Gel®; Theroxide® Wash [OTC];
Vanoxide®[OTC] |
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Generic
Available |
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Yes |
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Pharmacological Index |
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Topical Skin Product; Topical Skin Product, Acne |
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Use |
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Adjunctive treatment of mild to moderate acne vulgaris and acne
rosacea |
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Pregnancy Risk
Factor |
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C |
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Adverse
Reactions |
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1% to 10%: Dermatologic: Irritation, contact dermatitis, dryness, erythema,
peeling, stinging |
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Drug
Interactions |
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Increased toxicity: Benzoyl peroxide potentiates adverse reactions seen with
tretinoin |
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Mechanism of
Action |
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Releases free-radical oxygen which oxidizes bacterial proteins in the
sebaceous follicles decreasing the number of anaerobic bacteria and decreasing
irritating-type free fatty acids |
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Pharmacodynamics/Kinetics |
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Absorption: ~5% through the skin; gels are more penetrating than creams
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Usual Dosage |
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Children and Adults:
Topical: Apply sparingly once daily; gradually increase to 2-3 times/day if
needed. If excessive dryness or peeling occurs, reduce dose frequency or
concentration; if excessive stinging or burning occurs, remove with mild soap
and water; resume use the next day. |
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Dental Health: Local
Anesthetic/Vasoconstrictor
Precautions |
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No information available to require special precautions |
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Dental Health:
Effects on Dental Treatment |
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No effects or complications reported |
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Patient
Information |
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Shake lotion before using; cleanse and make sure skin is dry before applying;
may bleach color from fabrics; may be worn under makeup; improvement should
occur within 2 weeks; keep away from eyes, mouth, mucous membranes; expect
dryness and peeling; if excessive redness or irritation occurs, discontinue use;
avoid excessive sunlight, sun lamps, or other topical medication unless directed
by a physician |
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Nursing
Implications |
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Watch for signs of systemic infection; granulation may indicate
effectiveness |
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Dosage Forms |
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Bar: 5% (113 g); 10% (106 g, 113 g)
Cream: 5% (18 g, 113.4 g); 10% (18 g, 28 g, 113.4 g)
Gel: 2.5% (30 g, 42.5 g, 45 g, 57 g, 60 g, 90 g, 113 g); 5% (42.5 g, 45 g, 60
g, 80 g, 90 g, 113.4 g); 10% (30 g, 42.5 g, 45 g, 56.7 g, 60 g, 90 g, 113.4 g,
120 g); 20% (30 g, 60 g)
Liquid: 5% (120 mL, 150 mL, 240 mL); 10% (120 mL, 150 mL, 240 mL)
Lotion: 5% (25 mL, 30 mL); 5.5% (25 mL); 10% (12 mL, 29 mL, 30 mL, 60 mL)
Mask: 5% (30 mL, 60 mL, 60 g) |
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