Yes

Vitamin, Water Soluble

Prevention and treatment of scurvy and to acidify the urine

A/C (if dose exceeds RDA recommendation)

Large doses during pregnancy

Diabetics and patients prone to recurrent renal calculi (eg, dialysis patients) should not take excessive doses for extended periods of time

1% to 10%: Renal: Hyperoxaluria with large doses

<1%: Flushing, faintness, dizziness, headache, fatigue, nausea, vomiting, heartburn, diarrhea, flank pain

Symptoms of overdose include renal calculi, nausea, gastritis, diarrhea

Diuresis with forced fluids may be useful following a massive ingestion

Decreased effect:

Aspirin (decreases ascorbate levels, increases aspirin)

Fluphenazine (decreases fluphenazine levels)

Warfarin (decreased effect)

Increased effect:

Iron (absorption enhanced)

Oral contraceptives (increased contraceptive effect)

Injectable form should be stored under refrigeration (2°C to 8°C); protect oral dosage forms from light; is rapidly oxidized when in solution in air and alkaline media

Not fully understood; necessary for collagen formation and tissue repair; involved in some oxidation-reduction reactions as well as other metabolic pathways, such as synthesis of carnitine, steroids, and catecholamines and conversion of folic acid to folinic acid

Absorption: Oral: Readily absorbed; an active process and is thought to be dose-dependent

Distribution: Widely distributed

Metabolism: In the liver by oxidation and sulfation

Elimination: In urine; there is an individual specific renal threshold for ascorbic acid; when blood levels are high, ascorbic acid is excreted in the urine; whereas when the levels are subthreshold, very little if any ascorbic acid is cleared into the urine

Oral, I.M., I.V., S.C.:

<6 months: 30 mg

6 months to 1 year: 35 mg

1-3 years: 15 mg; upper limit of intake should not exceed 400 mg/day

4-8 years: 25 mg; upper limit of intake should not exceed 650 mg/day

9-13 years: 45 mg; upper limit of intake should not exceed 1200 mg/day

14-18 years: Upper limit of intake should not exceed 1800 mg/day

Males: 75 mg

Females: 65 mg

Adults: Upper limit of intake should not exceed 2000 mg/day

Males: 90 mg

Females: 75 mg;

Pregnant female:

less than or equal to 18 years: 80 mg; upper limit of intake should not exceed 1800 mg/day

19-50 years: 85 mg; upper limit of intake should not exceed 2000 mg/day

Lactating female:

less than or equal to 18 years: 15 mg; upper limit of intake should not exceed 1800 mg/day

19-50 years: 20 mg; upper limit of intake should not exceed 2000 mg/day

Adult smoker: Add an additional 35 mg/day

Children:

Scurvy: 100-300 mg/day in divided doses for at least 2 weeks

Urinary acidification: 500 mg every 6-8 hours

Dietary supplement: 35-100 mg/day

Adults:

Scurvy: 100-250 mg 1-2 times/day for at least 2 weeks

Urinary acidification: 4-12 g/day in 3-4 divided doses

Prevention and treatment of colds: 1-3 g/day

Dietary supplement: 50-200 mg/day

Monitor pH of urine when using as an acidifying agent

False-positive urinary glucose with cupric sulfate reagent, false-negative urinary glucose with glucose oxidase method; false-negative stool occult blood 48-72 hours after ascorbic acid ingestion

Rare reports of drowsiness; usually well tolerated

May decrease fluphenazine levels; clinical significance unknown but likely not problematic

No information available to require special precautions

No effects or complications reported

Take exactly as directed; do not take more than the recommended dose. Do not chew or crush extended release tablets. Take oral doses with 8 ounces of water. Diabetics should use serum glucose monitoring method. Report pain on urination, faintness, or flank pain.

Avoid rapid I.V. injection

Capsule, timed release: 500 mg

Crystals: 4 g/teaspoonful (100 g, 500 g); 5 g/teaspoonful (180 g)

Injection: 250 mg/mL (2 mL, 30 mL); 500 mg/mL (2 mL, 50 mL)

Liquid, oral: 35 mg/0.6 mL (50 mL)

Lozenges: 60 mg

Powder: 4 g/teaspoonful (100 g, 500 g)

Solution, oral: 100 mg/mL (50 mL)

Syrup: 500 mg/5 mL (5 mL, 10 mL, 120 mL, 480 mL)

Tablet: 25 mg, 50 mg, 100 mg, 250 mg, 500 mg, 1000 mg

Tablet:

Chewable: 100 mg, 250 mg, 500 mg

Timed release: 500 mg, 1000 mg, 1500 mg

Ballin A, Brown EJ, Koren G, et al, "Vitamin C-Induced Erythrocyte Damage in Premature Infants," J Pediatr, 1988, 113(1 Pt 1):114-20.

Giunta JL, "Dental Erosion Resulting From Chewable Vitamin C Tablets," J Am Dent Assoc, 1983, 107(2):253-6.

Korallus U, Harzdorf C, and Lewalter J, "Experimental Basis for Ascorbic Acid Therapy of Poisoning by Hexavalent Chromium Compounds," Int Arch Occup Environ Health, 1984, 53(3):247-56.

Lawton JM, Conway LT, Crosson JT, et al, "Acute Oxalate Nephropathy After Massive Ascorbic Acid Administration," Arch Intern Med, 1985, 145(5):950-1.

McAllister CJ, Scowden EB, Dewberry FL, et al, "Renal Failure Secondary to Massive Infusion of Vitamin C," JAMA, 1984, 252(13):1684.

Myrianthopoulos M, "Dietary Treatment of Hyperlipidemia in the Elderly," Clin Geriatr Med, 1987, 3(2):343-59.

Pru C, Eaton J, and Kjellstrand C, "Vitamin C Intoxication and Hyperoxalemia in Chronic Hemodialysis Patients," Nephron, 1985, 39(2):112-6.

Tunget CL, Clark RF, Manoguerra AS, et al, "Iron Overdose and Detection of Gastrointestinal Bleeding With the Hemoccult® and Gastroccult® Assays," Ann Emerg Med, 1995, 26(1):54-7.