|
Pronunciation |
|
(an
tee-in HI bi tor coe AG yoo lant
KOM pleks) |
|
|
U.S. Brand
Names |
|
Autoplex® T; Feiba VH
Immuno® |
|
|
Generic
Available |
|
No |
|
|
Synonyms |
|
Coagulant Complex Inhibitor |
|
|
Pharmacological Index |
|
Antihemophilic Agent; Blood Product Derivative |
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|
Use |
|
Patients with factor VIII inhibitors who are to undergo surgery or those who
are bleeding |
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|
Pregnancy Risk
Factor |
|
C |
|
|
Contraindications |
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Disseminated intravascular coagulation; patients with normal coagulation
mechanism |
|
|
Warnings/Precautions |
|
Products are prepared from pooled human plasma; such plasma may contain the
causative agents of viral diseases. Tests used to control efficacy such as APTT,
WBCT, and TEG do not correlate with clinical efficacy. Dosing to normalize these
values may result in DIC. Identification of the clotting deficiency as caused by
factor VIII inhibitors is essential prior to starting therapy. Use with extreme
caution in patients with impaired hepatic function. |
|
|
Adverse
Reactions |
|
<1%: Hypotension, flushing, fever, headache, chills, rash, urticaria,
disseminated intravascular coagulation, anaphylaxis, indications of protein
sensitivity |
|
|
Overdosage/Toxicology |
|
Rapid infusion may cause hypotension, excessive administration can cause
DIC |
|
|
Stability |
|
Store at 2°C to 8°C
(36°F to 46°F); use within 1-3 hours
after reconstitution |
|
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Usual Dosage |
|
Dosage range: 25-100 factor VIII correctional units per kg depending on the
severity of hemorrhage |
|
|
Test
Interactions |
|
PT,
PTT,
WBCT,
fibrin,
platelets,
fibrin split
products |
|
|
Mental Health: Effects
on Mental Status |
|
None reported |
|
|
Mental Health:
Effects on Psychiatric
Treatment |
|
None reported |
|
|
Dental Health: Local
Anesthetic/Vasoconstrictor
Precautions |
|
No information available to require special precautions |
|
|
Dental Health:
Effects on Dental Treatment |
|
No effects or complications reported |
|
|
Patient
Information |
|
This medication can only be given I.V. Immediately report backache, itching
or rash, difficulty breathing, acute feelings of anxiety, or sudden onset
headache. Pregnancy/breast-feeding precautions: Inform prescriber if you
are pregnant. Consult prescriber if breast-feeding. |
|
|
Nursing
Implications |
|
Monitor for hypotension, may reinitiate infusion at a slower rate; have
epinephrine ready to treat hypersensitivity reactions |
|
|
Dosage Forms |
|
Injection:
Feiba VH Immuno®, heparin free: Each bottle is labeled
with correctional units of Factor VIII
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Copyright © 1978-2000 Lexi-Comp Inc. All Rights Reserved
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