Acetaminophen and Dextromethorphan

Interactions with herbs

Milk Thistle

Interactions with supplements

S-Adenosylmethionine (SAMe)

Vitamin C (Ascorbic Acid)

Look Up > Drugs > Acetaminophen and Dextromethorphan

Acetaminophen and Dextromethorphan

	Pronunciation
	U.S. Brand Names
	Generic Available
	Pharmacological Index
	Use
	Warnings/Precautions

	Usual Dosage
	Dental Health: Local Anesthetic/Vasoconstrictor Precautions
	Dental Health: Effects on Dental Treatment
	Dosage Forms
	References

Pronunciation

(a seet a MIN oh fen & dex troe meth OR fan)

U.S. Brand Names

Bayer® Select® Chest Cold Caplets [OTC]; Drixoral® Cough & Sore Throat Liquid Caps [OTC]

Generic Available

Yes

Pharmacological Index

Cough Preparation

Use

Treatment of mild to moderate pain and fever; symptomatic relief of coughs caused by minor viral upper respiratory tract infections or inhaled irritants; most effective for a chronic nonproductive cough

Warnings/Precautions

Research on chicken embryos exposed to concentrations of dextromethorphan relative to those typically taken by humans has shown to cause birth defects and fetal death; more study is needed, but it is suggested that pregnant women should be advised not to use dextromethorphan-containing medications

Usual Dosage

Oral:

Adults: 325-650 mg every 4-6 hours or 1000 mg 3-4 times/day; do not exceed 4 g/day

Dental Health: Local Anesthetic/Vasoconstrictor Precautions

No information available to require special precautions

Dental Health: Effects on Dental Treatment

No effects or complications reported

Dosage Forms

Caplet: Acetaminophen 500 and dextromethorphan hydrobromide 15 mg

Capsule: Acetaminophen 325 and dextromethorphan hydrobromide 15 mg

References

Barker JD Jr, de Carle DJ, and Anuras S, "Chronic Excessive Acetaminophen Use in Liver Damage," Ann Intern Med, 1977, 87(3):299-301.

Dionne RA, Campbell RA, Cooper SA, et al, "Suppression of Postoperative Pain by Preoperative Administration of Ibuprofen in Comparison to Placebo, Acetaminophen, and Acetaminophen Plus Codeine," J Clin Pharmacol, 1983, 23(1):37-43.

Licht H, Seeff LB, and Zimmerman HJ, "Apparent Potentiation of Acetaminophen Hepatotoxicity by Alcohol," Ann Intern Med, 1980, 92(4):511.