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GABA shunt and tricarboxylic acid cycle functional activity in brain of morphine-dependent rats |
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GABA shunt and tricarboxylic acid cycle functional activity in brain of morphine-dependent rats
Vinitskaya A. G., Abazid H., Lelevich S. V., Lelevich V. V.
GABA shunt and tricarboxylic acid cycle functional activity in brain of morphine-dependent rats.
Summary: Influence of chronic morphine intoxication (ChMI) on activity of GABA shunt (GABA transaminase and succinic semialdehyde dehydrogenase) and TCA cycle (succinate dehydrogenase, NAD+-isocitrate dehydrogenase) enzymes in the rat brain regions has been studied. In the brain stem and thalamus, an increase in the NAD+-IDH and GABA-T activities was observed, which might express a simultaneous acceleration in the TCA cycle and GABA shunt reactions evoked by prolonged morphine administration. In the cerebellum, an inhibition of the TCA cycle and GABA turnover was detected, which was the most significant after the 21 days of ChMI. We propose that the shifts in the indices of the energy and GABA metabolisms are likely to be composed of a number of metabolic changes either in GABAergic neurons or surrounding astrocytes and occur due to morphine modulation of the µ-opioid receptors in the brain regions containing them.
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